不同固定方式下lmhfv治疗山羊长骨稳定性骨折最适频率的探究外科学专业论文.docxVIP

西南医科大学硕士学位论文大，另外a组振动参数对骨折愈合的促进作用强于b组振动参数。 西南医科大学硕士学位论文 大，另外a组振动参数对骨折愈合的促进作用强于b组振动参数。 2．血清动态监测显示实验组骨钙素浓度在实验前期和后期高于对照 组，中期略低于对照组。此结果提示了实验组在骨折恢复的过程中，更快 更有效地刺激了成骨细胞的生成和活化以促进骨折愈合，且更能持续地保 持成骨细胞的活化状态促进成骨；另外实验组的血清TRAP5b浓度在实验前 期及中期均明显低于对照组，到实验后期却高于对照组。该结果提示LMHFV 刺激样本在骨折恢复的前期抑制了破骨细胞的生成或活性状态来促进形成 骨痂以成骨，而后期经振动刺激的实验组样本更快进入了骨折愈合的改造 塑型期，加快了骨折愈合的进程。 3．相同愈合时间后实验组患肢掌骨、跖骨断端骨痂较对照组更致密、 规整、光滑，提示振动刺激下实验组的骨痂形成更为有效。 4．各组患肢掌骨、跖骨干力学性能检测提示：接受LMHFV振动刺激的 样本患肢骨折断端的弹性模量并无明显变化，同时在同一骨干骨折线以远 处的骨质弹性模量有所增强，利于骨生长。此外接受同一振动参数处理的 样本，并不会因固定方式的不同而出现明显的差异。 综上所述，在非陈旧性长骨干稳定性骨折的模型愈合过程中，施加适 当振动参数的LMHFV可有效地促进成骨作用和骨的重塑，进而加快骨折愈 合过程。另外相同Lt怔IFV振动参数，但接受不同固定方式，对骨折愈合无 显著影响。 关键词：骨折；振动刺激；愈合；固定方式 万方数据 西南医科大学硕士学位论文Comparative 西南医科大学硕士学位论文 Comparative study of the proper parameter of LMHFV when used for goats’stable long bone fracture treatment under different fixed way Abstract：Objective：Positive promotion effects of LMHFV(Low— magnitudehigh—frequency vibration)have been proved for fracture healing in the fields of cytology and biology．HoweveL there is few research about how LMHFV effects the fracture injury of live big size mammal．Besides，the lack of articles’ talking about the comparisons between the different vibration parameters and the difference between intemal fixation and extemal fixation in the present literatures really evoke my interests doing the first initial research．My research is trying to explore the appropriate motion parameter of LMHFV when using it to facilitate the fracture healing process of long bone，and provide trustful theoretical evidence for clinical experiments through comparing the healing results of fracture healing’S different managements． Methods：The samples were comprised of 1 2 healthy female goals with same age as 8 months and their weights ranged from 1 7kg to 20kg．After equally distributing all these samples into six different groups at random，Metacarpal and metatarsal transverse osteotomy had been implemented to them under same anesthetic and aseptic condition．I used my grouping proc