pcg蛋白hpc2的生物信息学分析及其在不同hpv感染状态的宫颈癌细胞中的表达研究妇产科妇科肿瘤专业论文.docxVIP

Bioinformatics Bioinformatics of HPC2 and the expression of PcG protein HPC2 in cervical carcinomas infected by different HPVs Abstraet： Objective：Cervical cancer is the common disease of women malignant tumor，it’S a serious threat to women’S life and health．As a developing country， the new case rate of cervical cancer of china iS 30％of the world．Cervical cancer patients have been growing at 2％to 3％a year．And in recent years．the maj ority of cervical cancer census showed the onset age tend to be younger．Now there are a large number of studies have shown that HPV infection，especially the high-risk type HPV infection is the vast majority of the main cause of cervical precancerous lesions and cervical cancer．And HPV 1 6 and HPV 1 8 are the most common types．PcG gene(Polycomb group)is a new discovered cancer-related gene in recent years．Emerging evidence suggests that PcG plays an important role in the stability of homologous abnormity gene in Drosophila development．It play S an critical role in embryonic development，tumor occurrence，tumor metastasis and maintaining stem cells．Now a number of studies have shown that PcG is a oncogene， participating in nasopharyngeal carcinoma，breast cancer，lung cancer， bladder cancer and many other kinds of human tumor occurrence and development．HPC2 is a member of the PcG gene family，and it is tested out that there is a lot of expression in a variety of cancers．The existing studies have confirmed that the PcG protein HPC2 can induce cancer cell apoptosis， 3 万方数据 regulate regulate cell growth，etc．It also had been confirmed that HPC2 is oVerexpression incervical cancers Compared with the normal cervical tissue，however the mechanism of HPC2 protein in cervical cancer is still unknown，needing further study．Further understanding and researching of HPC2 bioinformatics functions and its relationships with cervical cancer are needed，aiming to provide a new direction for the research of the pathogenesis of cervical cancer occurrence．In this