对dna微阵列数据的聚类以识别阿尔茨海默病的相关基因计算数学专业论文.docxVIP

四川师范大学硕士学位论文 四川师范大学硕士学位论文 万 万方数据 万方数据 万方数据 11 Classify Classify Experiment Conditions of DNA Microarray Data and Identify the Genes Associated with Alzhimer’S Disease Major：Computational Mathematics Postgraduate：Chen Yingying Supervisor：Pang Chaoyang Abstract Alzheimer’S disease named AD，It is a more severe dementia AD still mav not charm away at present and will persist in deteriorating，TO explore the Dathogenesis of Alzheimer’s disease is to find the genes which cause Alzheimer’s disease．By design algorithms，identify with Alzheimers disease。related candidate genes，and thus expect to find ways to treat the disease· Cluster analysis also known as clustefng．It let the things divide into different， and can be used the thing in same subject ofhigh similarity，but the opposite may not· It caIl give rise to detect the new thing where we never find OUt tO forestall it．mis method will be adhibited to identify candidate genes of AD． In this words，，the Gene data are classified into different classes SO that the data included in same class are generated under similar experiment conditions and di妇ferent class corresponds to significantly different conditions．Then through centroids with all possible，upregulated(downregulated)genes are extracted·If the extracted gene keeps invariant expression feature under all experiment conditions，It may selected as the candidate gene． Using the method。1 44 genes are identified and 8 genes agree with other research te锄s’results．To analysis genes for their function and position，there have three conclusions may result in the Alzheimer’S disease：Firstly：The candidate genes that 曲01ved in signal仃ansducfion may be associated with AD．；secondly：The neuroblast fails to proliferation that may generate to AD，and the last：Alzheimer’S disease’s candidate genes may be associate with zinc ion binding genes．The expression of genes unusually in the signaling pathway abnormalities．：Finally,a few genes associated with AD diagram． Keywords：AD，gene，DNA microarray