含铁蛋白介导铁转运分子机制.pdfVIP

第 19 卷 第 12 期 化　学　进　展 Vol. 19 No. 12 2007 年 12 月 PROGRESS IN CHEMISTRY 　Dec. , 2007 含铁蛋白介导的铁转运分子机制 孙雪松　何庆瑜 (暨南大学生命与健康工程研究院 　广州 510632) 摘 　要 　铁是生命体必需的微量元素 ,因为它是一些重要功能酶的协同因子。这些功能酶有着广泛的 功能 ,从呼吸作用到核酸的复制。但是 ,当铁含量多于细胞稳态时 ,它将产生对机体有毒的羟基。生物体已 经发展了自身的调控机制 ,包括铁的摄取、存储和输出来控制细胞内的铁处于平衡态。二价阳离子转运蛋 白、铁输出蛋白和hephaestin 参与小肠吸收。转铁蛋白和转铁蛋白受体参与铁的摄取和转运 ,铁蛋白可以存 储铁 ,铁调控蛋白的功能是调节铁代谢。本综述着重阐述了含铁蛋白介导的铁传递机制。 关键词 　转铁蛋白 　转铁蛋白受体 　二价阳离子转运蛋白 　铁蛋白 　铁调控蛋白 ( ) 中图分类号: Q581 　文献标识码 : A 　文章编号 : 1005281X 2007 Molecular Mechanism of Iron Transport Mediated by IronContaining Proteins Sun Xuesong 　He Qingyu ( Institute of Life and Health Engineering , Jinan University , Guangzhou 510632 , China) Abstract 　Iron , an essential element for virtually all organisms , is required as a cofactor for many enzymes that are involved in various cellular functions ranging from respiration to DNA replication. On the other hand , iron is also toxic when in excess over cellular homeostasis due to the generation of hydroxyl radicals through Fenton reaction. Organisms have developed mechanisms to control cellular iron levels by closely modulating the iron uptake , storage and efflux. DMT1 (divalent metal transpoter) , ferroportin , hephaestin are involved in intenstinal iron absorption. Transferrin and transferrin receptors participate in cellular iron uptake and transport , whereas ferritin functions as an iron strorage protein , and IRP (iron responsive protein) regulates iron metab