姜黄素对酒精性肝损伤保护作用的实验研究内科学消化系病专业论文.docxVIP

优秀毕业论文 精品参考文献资料 兰州大学壤± 兰州大学壤±学位论文 达增强，面在各姜黄素治疗组大鼠肝组织中表达减弱。HE染色示模型组大鼠肝细 胞出现不同程度的脂肪变性，伴有点、灶状坏死，炎性细胞浸润，各姜黄素治疗 组肝脏病理变化不圆程度的轻于模型组。 绪论 姜黄素能通过抑制溪精中毒大鬣脂震过氧化纛肝组织中嗣陶国的表 达，从而减轻或防治滔精诱导的脬损伤。 关键谲滔糟性翳瘸；姜黄素；脂质过氧化；核因子稿 Ⅱ 兰媸大学硕士学使论文 兰媸大学硕士学使论文 Protection of curcumin on alcoholic liver mjury In mts Abstract Objective To reproduce an experimental model of alcoholic liver injury in rats and to investigate the effects of cancumin on lipid pcroxidation and expression of nuclear factor KB induced by ethanol in rats． Methods 40 Sprague-Dawley rats were randomly divided into five groups(8 rats／group)：control group，model group,curcumin treatment(40’80，1 60mg／kg) groups．control group intragastdcally infused with normal saline，the other groups intragastfically infused with 56％(v／v)of ethanol,6．729／(kg．d)，after 6 weeks, ourcumin treatmem(40，80，160mg／kg)groups respectively added curcumin 40mgg,80mg／kg,160mg／kg。At the end of 12 weeks,all rats were killed．Levels of serum ALT,AST,ALP were measured。SOD,MDA,NO contents in the liver tissue were determined．The expression of NF-v,B in the liver tissue were determined with immunohistochemical analysis and liver samples were obtained for routine histological examination． Results The serum铷旺AST,ALP levels and the contents of MDA,NO in the liver tissue were significamly increased in model group than in control group (86．4圭7．5塔33．5壬10．3，201．04-16．8塔1 16．54-12．q 205．14-20．0倦104．征9．4 3．29-x-0．34蜷1．354-0．12，4．37：L-0。21醛2．724-0．13，PO．01)SOD activity wag markedly decreased(80．21a：4．55vsl80。244-27，53，po．oi)．However,curcumin treatment groups markedly degraded the levels of serum触已TAST,ALP,as well as the contents ofMDA,NO in the liver tissue(66．5士9．6／52．4a：12．0／40．94-7．9 vs86．诎7．5’ 1 71．44-10．8／145．84-1 1．9／135．啦11．8Ⅷ201．0-圭16．8，76．4+13．7／146．94-13．8／127．1+12．6 雠205．1圭20．0，2．844-0．2711．95：b-0．23／1．954-0．23懈3．29i0．34，4．01圭O．17／3．604-0．16／ 嫩 兰州大学硕士学位论文3 兰州大学硕士学位论文 3．6Q士0．16倦4．37=L-0．21，p0．05 or PO．01)．Inversely,the SOD activity was elevated (92．36士6．4711 17．69圭21．