杭州高脂血症患者血小板磷脂膜脂肪酸及其它心血管疾病危害因子的研究-食品科学专业论文.docxVIP

堕生丝兰堕茎兰丝苎丝鲨竺塑丝些塑!坚!多 堕生丝兰堕茎兰丝苎丝鲨竺塑丝些塑!坚!多 昔血清尿酸显著性高于同性别健康人。高脂血症患者更易诱发一tL,脑血 管疾病。该人群的总胆固醇水平与低密度脂蛋白、高密度脂蛋白及血 清片油三酯水平显著性正相关；血清甘油三酯与高密度脂蛋白显著性 负相关，而与血清尿酸及凝血因子Ⅶ显著性正相关。此外，高脂血症 患者TXB：显著低于健康对照组，可能为高脂血症患者比健康人食用 较多的动物性脂肪。研究未发现高脂血症患者和健康对照组血小板磷 脂膜脂肪酸成份存在显著性差异，这说明高脂血症患者和健康人饮食 中的脂肪成份相似。杭州地区人群血小板磷脂膜脂肪酸主要成份依次 有花生四烯酸、软脂酸、硬脂酸、油酸、亚油酸、廿碳五烯酸、廿二 碳六烯酸等。此外，与澳大利亚高加索人群比较，杭州地区人群血小 板磷脂膜含有较高的总多不饱和脂肪酸与廿碳五烯酸、廿二碳六烯 酸，以及较高n-3／n．6多不饱和脂肪酸比例。 结论：杭州地区高脂血症患者身体质量指数、凝血因子Ⅶ的活性 比对照组高，而TXB：比对照组低，男性血清尿酸浓度高于同性别健 康人。相似的血小板磷脂膜成分说明高脂血症患者和健康对照组饮食 中的脂肪成份相似。杭州地区人群高的血小板磷脂膜n．3多不饱和脂 肪酸成分表明饮食中n．3多不饱和脂肪酸的摄入高，这可能是该地区 一tL,脑血管疾病发病率和死亡率低的原因之一。 关键词：高脂血症，血小板磷脂膜脂肪酸，心血管疾病危害因子，n．3 多不饱和脂肪酸，杭州地区 IJ 抗他地选赢瞻盘症卷者s毽褒对照组妇小板磷§目黩疆骑馥战分及其它om管庆翕危害囟予的研究PLATELET 抗他地选赢瞻盘症卷者s毽褒对照组妇小板磷§目黩疆骑馥战分及其它om管庆翕危害囟予的研究 PLATELET MEMBRANE PHOSPHOLIPID FATTY ACID AND OTHER CARDl0VASCULAR DISEASE RISK FACToRS IN HYPERLIPIDEMIA SUBJECTS IN HANGZHoU ABSTRACT In the recent two decades，traditional Chinese soy-pork dietary pattern has changed．Malnutrition diseases are dramatically declined， however the nutrition—imbalanced related non—communicable(chronic) diseases are increased，which has became the leading killer,especially cardiovascular disease(CVD)．CVD is mainly caused by atherosclerosis， and hyperlipemia is dominating risk factor for atherosclerosis．The dietary fats(1ipids)intake and fatty acid composition of fats are associated with serum／plasma and lipoprotein lipids．However it is impossible to accurately calculate the content of lipids and fatty acids， and their compositions in free living Chinese diet，due to it’s very rare for people to prepare their three meals at home in Hangzhou region，they never know what sort of and how much fats have been used in preparing food at eatery or restaurant．Therefore，we used platelet membrane phospholipids(PL)fatty acid compositions as a biomarker of the dietary fat intake in this study． The 86 hyperlipidemia subjects aged between 30～78 Y(male 53， female 33)．and agesex—matched 82 health subjects aged between 24～ 74 Y(male 55，