基于DR成像系统的锥束CT成像研究-生物医学工程专业论文.docxVIP

ABSTRACT Digital Radiography (DR) imaging equipment has been widely used in clinical practice and gradually spread to the primary medical institutions in our country. Accurate performance assessment of DR imaging equipment is the prerequisite to ensure its rational clinical application, so it has important application value. The International Electrotechnical Commission adopted modulation transfer function(MTF) for performance evaluation of DR imaging equipment, and recommended knife-edge method as one of the MTF measurement method. Knife-edge method has advantages in accurately obtaining the low-frequency characteristics of MTF, but the error in tilt angle measurement of the knife-edge object prevents accurate MTF estimation in high frequencies. This problem has become one of the major concerns in this research area around the world. A novel method for precise MTF measurement based on interpolation floating technique was proposed in this paper. By investigating the quantitative relationship among the interpolation floating value, the variation of the line spread function (LSF), and the attenuation characteristics of the MTF curves in the presence of noise, we demonstrated that the tilt angle measurement error caused the interpolation number deviation from the ideal benchmark interpolation and resulted in worse smoothness of the LSF curves and higher attenuation level of the MTF curves than the actual one. The MTF measurement error due to the edge angle measurement error was effectively relieved by using the interpolation floating method. This method has great application value because it reduced the tough requirements in high-precision angle measurement of MTF estimation According to the cone-beam CT imaging theory and the performance evaluation results of the DR system, a multi-dimensional and semi-automatic cone-beam imaging platform was built for three-dimensional imaging of small animals. The calibration phantom was designed for the calibration of the cone-bea