京尼平交联脱细胞羊膜预防兔跟腱粘连-外科学专业论文.docxVIP

万方数据 万方数据 目录 中文摘要····························································································· （1） 英文摘要····························································································· （2） 论文题目····························································································· （3） 前言··································································································· （4） 材料与方法·························································································· （5） 结果··································································································· （8） 讨论··································································································· （10） 结论··································································································· （14） 参考文献····························································································· （16） 文献综述····························································································· （20） 参考文献····························································································· （29） 缩略语表····························································································· （32） 攻读学位期间发表文章情况····································································· （33） 个人简历····························································································· （34） 致谢··································································································· （35） 内蒙古医科大学硕士研究生学位论文（2015） 1 中 文 摘 要 目的 观察京尼平（Genipin，GN）交联脱细胞人羊膜（human acellular amniotic membrane，HAAM）对兔跟腱粘连的预防效果，为临床中探寻理想 的防粘连生物膜提供依据。方法 18 只家兔随机分为 3 组、每组 6 只，锐 性横向完全离断双后肢跟腱后肌腱断端行改良 Kessler 法缝合，自跟腱断 端切除部分腱膜；Ａ组（GN + HAAM 组）12 根跟腱缝合后用京尼平交联脱 细胞人羊膜包裹；Ｂ组（HAAM 组）12 根跟腱用脱细胞人羊膜包裹,C 组（对 照组）12 根跟腱单纯缝合，术后石膏固定 5 周；术后第 5 周对标本进行肉 眼观察、生物力学测定、电镜观察。 结果 各组跟腱粘连评分为Ａ＜Ｂ＜ Ｃ（Ｐ＜0.05）。生物力学测定无明显统计学差异（Ｐ＞0.05）。电镜显 示Ａ组交联脱细胞人羊膜未降解，羊膜与肌腱间仅见局灶少许疏松粘连， 存在成纤维细胞，部分可见淋巴细胞，胶原纤维排列规