降氮汤治疗慢性肾功能衰竭的临床与实验研究-中医内科专业论文.docxVIP

鹭46505 鹭46505 9 提要 目的：_|ijf究和探讨降氮汤治疗慢性肾功能衰竭(CRF)的临昧 疗设刺f，r川原埋。方法：l将患揣随机分为治疗纽和对照组锌30例， 分别J|挺川降瓤汤和尿毒消颗粒。2．结合动物实验的对照研究。结果： 1．降氮汤能}嘲显改薅消化道症状及体力等一般情况，显著降低球篮 一，m脂f¨脏Scr、BUN，』￡总fj效率86 67％，显酱优十抹毒消对 照组LP005)。2．吏验发现降氮汤可通过降低虹ET，I、叫j匕、球畿 f’f等途价抑制CRF的渐进性发展机制，减轻’阡小球硬化和’ffdH：-问 质纤维化，其有肾保护作『玎。结论：降纽汤从多靶点、多途径m断 CRF渐进性发展机制，保护肾脏功能，j}仃提岛患揣-，}i活质最，延 避进入逸钒时{H1详3{乍{11，遗治疗CRF桷有数力弱。 关键诃：降氮汤慢性肾功能衰竭临床观察实验研究 ＼／ 、7＼／∥ Clinical Clinical and expel‘imental study of．1iangdan Decodion in treating ch ronie iellal faiiu llc Speciality： Urinary medicine oFI、CM AuthOr： Dong xiuli Tufor： Prof I。i changhua Abstract Objeeti’e：To study and explore the clinical curative effect and active mechanism of Jiangdan Decoction“DDl in treating chronic renal failure(CRF)Methods：1．60 cases of CRF patients、、’ere randomly divided into 2 groups rfhe treatment group(30 cases)were given JDD，and the control group(30 cases)were treated Niaoduqing pellets 2．Combine the case—control study of animal experiment Result：1．JDD call significantly imprm，c the digestive s3’stem symptoms and physical strength of CRF patients It can also reduce the urine protein．plasma lipids，BUN and Scr notably’fhe total eflkctive rate of treatment group is 86 67％，better than that ofcontrol group(PO 05)．2．一l he experiment revealed．IDD can restrain the crescendo—developed mechanism of CRF,which is achie、_ed by decreasing blood E’r—I，plasma lipids，urine protein etc It also can lighten glomerular sclerosis，inhabit uriniferous tubule—interstitial fibrosis All these proved that JDD possess the quality of protecting renal function Condusions：JDD can impede the crescendo—developed lnechanism of CRF from various target points，protect renal function，improx’e the patients’life qualifies，thereby delay the time before entering dialysis therapy Key words：Jiangdan Decoction：chtonic rcnat failure；clinical study： cxperimentaI study 引 引 言 慢性肾功能衰竭(CRF)是常见瘸、疑难瘸。CRF时肾脏排泌 功能减退，体内代谢废物游留，水、电解质和酸碱、F衡紊乱，病情 复杂多变，严重危鲁若人类健康，甚至危及生命