改进的τ-leap算法在生化反应系统随机模拟中的应用-物理化学学报.PDF

27 3 Vol. 27 No. 3 20095 JOURNAL OF APPLIED SCIENCES — Electronics and Information Engineering May 2009 : 0255-8297(2009)03-0266-06 -leap 1. 200444 2. 200234 3. 200234 4. 241000 : -. -leap(improved -leap). SSA -leaping -leap(modified -leap). -leap -leap . : - -leap : O644 : A Application of Improved -leap Algorithm in Stochastic Simulation of Biochemical Reaction Systems LIU Huan , PENG Xin-jun , ZHOU Wen , WANG Yi-fei 1. Department of Mathematics, Shanghai University, Shanghai 200444, China 2. Department of Mathematics, Shanghai Normal UniversityShanghai 200234, China 3. Scientific Computing Key Laboratory of Shanghai Universities, Shanghai 200234, China 4. Mathematics and Computation College, Anhui Normal University, Wuhu 241000, Anhui Province, China Abstract: A -selected strategy that ascertain the value is proposed in this paper. It is developed as an improved -leap algorithm. The -selected strategy can effectively reflect change numbers of the species in biochemical systems, while the improved -leaping algorithm is more effective and practical to stochastic simulation of biochemical reaction systems than other algorithms. We take two models of biochemical reaction systems as examples, and carry out simulation using accurate SSA algorithm, improved -leaping algorithm, and the present modified -leap respectively. Numerical results demonstrate that, compared wit