2型糖尿病大鼠模型主动脉MMP-1、TIMP-1的表达变化和血管壁胶原代谢改变及吡格列酮的干预效应.pdfVIP

英文摘要 The of MMP．1，TIMP．1in Expression of T2DM Ratsandthe Macroangiopathy Effectof Therapeutical Pioglitazone ABSTRACT Objective：Therateof in morbidity macroangiopathy diabetic is3to5times of complication non．diabetic．Itisthe ofdiabeticandmain majorcomplication reasonforthe diabetic’Smutilationand death．The early abnomalmetabolism ofthe diabeticscausethe of arteries．Themain dysfunction modules such弱long—term resistence，leadto dyslipidemia，insulindiabetic complicating with macroangiopathy．But thechief atherosclerosis(AS)is of process between macroangiopathy．Theclosely relationship diabeticand atherosclerosisshowthatthe diabeticsoccursAS earlierandmore havebad seriously，andthey prognosis．The recent showsthatmatix study relatedtothe ofdiabetic withAS． developmentcomplicating Peroxisome Proliferator-activated