不同孕周与孕中期唐氏综合征筛查效率分析.docxVIP

不同孕周与孕中期唐氏综合征筛查效率分析 新疆石河子大学医学院第一附属医院，832000) 【摘要】目的：通过对新疆石河子地区各孕周孕妇唐氏综合症的风险状况分析, 以期得到木地区筛查效率较高的孕周，为临床提供参考数据。方法用时间分辨 法检测1331例孕中期15~20 + 6周母体三联血清标志物浓度，运用专业的产筛软 件进行胎儿风险评估，对比不同孕周唐氏综合征高风险和患儿检出率。结果孕 周与唐氏综合征筛查假阳率相关，＞L孕周在16-18+6周的检击率最高，为100%, 筛查结果假阳性率为4.44%。结论孕中期唐氏综合征筛查最佳孕周段为16-18+6 周。 关键词：孕中期；唐氏综合症筛查；孕周；假阳性率 Analysis of the efficiency of screening for Downs syndrome in secend pregnancy accordi ng to d iff ere nt gestatio nal weeks Hong Lil Yu Wei2(The First Affiliated Hospital of Xinjiang Shihezi University Medical College,832000), [abstract] objective: Through the analysis of the risk status of the pregnant women with Down syndrome in Shihezi District of Xinjiang, get the high screening efficiency of the gestati onal week, and provide ref ere nee data for clinical. Methods: Time resolution method was used to detect the maternal serum triple biomarker concentrations of 1331 puerpera during second trimester 15 to 20 + 6 weeks of and professional production was applied for fetal risk assessment software screen .Detection rate and high risk of infants with Dowrfs syndrome were compared between different gestational weeks. Results: the rate of false positive in screening for Downs syndrome was related to gestational age, and the detection rate of gestational week was the highest at 8+6 weeks, 100%. The false positive rate of screening was 4.44%. Conclusions: the optimal gestational week period of Downs syndrome screening in the second trimester of pregnancy is 16? 18+6 weeks. Key words: second trimester of pregnancy; Down syndrome screening; gestational age; false positive rate 唐氏综合征(Downs syndrome, DS)又称21三体综合征，是一种常见的 染色体异常疾病，其病因为21号染色体上多了一条染色体所致，患者常表现为 先天智力低下，面容特殊，发育迟缓等⑴，目前无有效的药物或治疗方法治疗 该疾病，由于其不可愈性，给患儿家庭以及社会带来经济、生活的负担。因此, 通过产前筛查，查出高风险人群，再对其进一步诊断可有效减少异常胎儿出生, 提高人口岀生素质。现将我院2014年11月?2016年6月孕中期1331例孕妇作 为研究对象，对孕中期孕周与唐氏综合征筛查效率之间的关系进行分析，现报道 如下： 1资料与方法 1.1 一般资料 收集2014年口月17 E1-2016年6月8日期间新疆石河子地区来我院 产前检查的孕妇1331例，年龄18-35岁，研究对象纳入标准：(1)单胎妊娠； 孕周在15-20+6周内。孕周估算：月经规律且明确末次月经时间按末次月 经推算孕周，月经不规