miR205与乳腺癌关系的研究进展.docxVIP

miR-205与乳腺癌关系的研究进展 胡蕴慧刘蕾张瑾 医学研究中心，天津市〃肿瘤防治〃重点实验室，乳腺 癌防治教育部重点实验室 摘要： 微小RNA (miRNAs)作为一类进化保守的非编码RNAs,通过与靶基因mRNA的序 列互补配对抑制其翻译或启动降解来发挥作用。越来越多的研究结果证实， miRMs通过发挥促癌或抑癌作用参与调控多种肿瘤的发生与发展。其中miR-205 在乳腺癌组织屮表达普遍降低，将miR-205在乳腺癌细胞屮过表达，则其能够 通过抑制表皮生长因子受体3 (ERBB3)、锌指E-盒结合同源异形盒(ZEB) 1、 ZEB2、血管内皮生长因子A (VEGFA)等靶基因的表达，从而抑制癌细胞增殖、 转移与侵袭能力，最终影响乳腺癌的治疗敏感性与预后。木综述重点阐述了 miR-205在乳腺癌中对细胞增殖、凋亡、侵袭、转移等相关基因及信号通路的调 控作用与机制，ndR-205与乳腺癌患者治疗敏感性以及患者预后的相关性，以期 为乳腺癌的诊断、治疗及预后判断提供新的思路与治疗靶点。 关键词： 微RW;乳腺肿瘤;基因疗法;受体，表皮生长因了;血管内皮生长因了 A; 锌扌旨E_盒结合同源异形盒;miR-205; 作者简介：胡蕴慧(1986),女，博士，讲师，主要从事乳腺肿瘤研究 作者简介：张瑾 E-mail:zhangjin@tjmuch. com 收稿日期：2017-06-09 基金：天津市自然科学基金项目(17JCQ町C09900) Research progress in correlation of miR-205 and breast cancer HU Yun-hui LIU Lei ZHANG Jin The 3rd Department of Breast Cancer, Tianjin Medical Universi ty Cancer Ins titute and Hosp it al, National Clinical Research Center of Cancer, Tianjin Breast Cancer Prevention, Treatment and Research Cent er, Key Labors tory of Breas t Cancer Prevent ion and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy; Abstract： As evolutionarily conservative small non-coding regulatory RNAs, micro RNAs (miRNAs) are capable ofsilencing gene expression by translational repression or m RNA degradation through complementary base pairing with them RNA of target genes. Accumulating evidence indicates that dcrcgulation of miRNAs is often associated with humanma 1 ignancics because miRNAs can function as oncogenes or tumor suppressors. Among them, miR-205 is significantlyunderexpressed in breast tumors. Overexpression of miR-205 in breast cancer cells significantly inhibits cell proliferation, invasion and metastasis through repressing the express!on of human epidermal growth factor receptor 3 (ERBB3) 、 zinc fingcrE-box binding homeobox 1 (ZEB1) , zinc finger E~box binding homeobox 2 (ZEB2) , vascular endothelial growth factor A (VEGFA) and other target genes, which affects therapeutic sensitivity and prognosis of breast cancer patients. This articlereviews the r