联检NSE、CYFRA211、D二聚体、Fib在肺癌患者中的临床意义.docxVIP

联检NSE、CYFRA21-1 D-二聚体、Fib在肺癌患者中的临床意义 谢颖贾张军张云生 (江苏省肿瘤医院检验科江苏南京210009) 【摘要】联合检测神经元特异烯醇化酶(NSE)、细胞角蛋口 19片段 (CYFRA21-1)D-二聚体(D?D)、Fib(纤维蛋白原)，探讨其在肺癌患者中的临床意义。 方法 肺癌组(256例)、肺良性疾病组(200例)和正常对照组(200例)的血清NSE、 CYFRA21-1水平采用电化学发光分析法检测，血浆D?二聚体、Fib水平采用免疫 比浊分析法检测，对肺癌患者NSE、CYFRA21-1 D?二聚体、Fib水平与临床分期 关系进行统计学分析。结果 肺癌组血清NSE、CYFRA21-1 D?二聚体、Fib水平 与肺良性病与正常对照组相比，差异具有统计学意义(P|t;0.01)。小细胞肺癌 (SCLC)屮NSE的水平最高，CYFRA21-1在非小细胞肺癌组(NSCLC)屮的肺鳞癌屮的 水平最高，与其他肺癌组比较，差异均具有统计学意义(Plt;0.05)o单项参数在 肺癌初诊中的皱感性为NSEgt;CYFRA21-lgt;D-二聚体gt;Fibo小细胞肺癌屮 NSE的敏感度最高(68.4%)，肺鳞癌屮CYFRA21-1的敏感性最高(69.0%)。NSE、 CYFRA21J、D■二聚体、Fibrinogen联合检测可以明显提高肺癌诊断的敏感性 (89.8%)o肺癌患者NSE、CYFRA21-1 D?二聚体、Fib水平与临床分期也呈正相关 (相关系数(r)分别为0.615, 0.425, 0.669, 0.523, Plt;0.05),且随着临床分期的 增加而升高,UI/IV明显高于 I/II期(Plt;0.05)o 结论 NSE、CYFRA21J、D■二 聚体、Fib的联合检测对肺癌的诊断、鉴别诊断、病情监测等方面具有重要的临 床价值。 【关键词】肺癌NSE CYFRA21-1 D?二聚体 纤维蛋白原 【屮图分类号】R730.4 【文献标识码】A 【文章编号】2095-1752 (2014) 18-0038-03 Clinical significanee of the combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen for the patients with lung cancer* XIE-Ying, YAN FengA, WANG Xiaoming, JIA Zhang-jun (Department of clinical laboratory, Jiangsu Cancer Hospital, Nanjing, Jiangsu, 210009, China) 【Abstract] Objective To discuss the clinical significanee of the combined determi nation of NSE,CYFRA21 D-Dimer, Fibri nogen for lung can cer patie nts. Methods The levels of serum NSE and CYFRA21-1 were detected by electrochemical analysis in 256 lung cancer patients, 200 patients with benign lung diseases and 200 health subjects. The levels of plasma D-Dimer and Fibri no gen were detected by immunoturbidimetric assays. The relationship of NSE, CYFRA21-1, D-Dimer and Fibrinogen levels with the clinical stages of lung cancer was analyzed by statistics. Results The levels of NSE, CYFRA21-1, D-Dimer and Fibrinogen in patients with lung cancer were sign讦icantly higher than those in patients with benign lung diseases and healthy con trols(Plt;0.01).The patie nts with squamous cell carci noma had the highest level of CYFRA21-l,and the