重复经颅磁刺激治疗儿童多发性抽动症疗效观察.docxVIP

重复经颅磁刺激治疗儿童多发性抽动症疗效观察 陈洁 (甘孜州人民医院内四科 626000) 【摘要】目的 观察重复经颅磁刺激(rTMS)对多发性抽动症(TS)患儿的 疗效。方法 将41例TS患儿随机分为假刺激组(n=20)和治疗组(n=21)o 2组患 儿均接受1HZ、110%静息运动阈值、5次/周、1200脉冲/次、共计4周的rTMS 治疗，假刺激组患儿接受假刺激线圈给予的rTMS治疗。于治疗前、治疗2周末 及8周末，采用耶鲁综合抽动严重程度量表(YGTSS)评估TS患儿疗效。结果与 治疗前比较，治疗组患儿经rTMS治疗2周、8周后，其YGTSS评分较治疗前显 箸降低，差异具有统计学意义(plt;0.05)；与治疗前比较，假刺激组患儿治疗2 周、8周后YGTSS评分与治疗前比较，差异无统计学意义(plt;0.05)o结论rTMS 可明显改善TS患儿的临床症状，值得临床推广应用。 【关键词】重复经颅磁刺激 多发性抽动症 辅助运动区 儿童 【中图分类号】R720.5 【文献标识码】A 【文章编号】2095-1752 (2014) 02-0122-02 Effects of low frequency repetitive transcranial magnetic stimulation for Tourettersquo;s syndrome. Chen Jie The fourth General Medicin巳 Ganzi peoplersquo;s hospital, 626000, Sichuan Provinee, China. [Abstract】 Objective To investigate the effects of low frequency repetitive transcranial magnetic stimulation for children with Tourettersquo;s syndrome （TS）?Methods Thirty-one subjects with TS were randomly assigned to either the treatment group（n二21） or the sham rTMS treatment group（n二20）. The rTMS treatment(lHZ、110% rest motor threshold x 5 sections/week 1200 pluses/section、 4 weeks) was given to treatment group subjects. For the sham group, the subjects received the same management process as those in the treatment group, but with a sham coil. The Yale global tic severity scale(YGTSS) was used to evaluate clinical performanee of subjects at before treatment, 2 and 8 weeks post-treatment, respectively. Results Compared with the YGTSS score at baseline level, the sham rTMS group showed no sign讦icant improvement at 2 and 8weeks after treatment (pgt;0.05); Compared with the YGTSS score at baseline level, the rTMS group showed sigrdficant improvement at 2 and 8 weeks after treatment (plt;0.05)? Conclusion The low frequency rTMS has the potential to improve the clinical condition in children with TS? 多发性抽动症(Tourettersquo;s syndrome, TS)是一种以慢性多发运动性 抽动和(或)发声抽动为主要特征的神经精神性疾病，在儿童中的发病率约 0.05%⑴。TS症状常持续数年，不仅严重影响患儿生活质量，妨害其身心健康, 还影响其家庭和睦。TS病因尚未完全阐清，现有治疗手段存在诸多局限性，因 此，寻找安全有效的TS新疗法迫在眉睫。重复经颅磁刺激(repetitive transcr