胆汁酸核受体FXR在胆汁淤积及其药物治疗中的研究进展.pdf

鑽鐮旂┒ 淼帮吉锝忥綍锝掞綆锝侊綄 锝忥絾 锛帮綀锝侊綊锝嶏絹锝冿絽锝曪綌锝夛絻锝侊綄锛诧絽锝擄絽锝侊綊锝冿綀 锛掞紣锛戯紭 锛讹綇锝?锛擄紬陰籍锝?锛 淼帮紤锛栵紮 淼 鑳嗘眮閰告牳鍙椾綋 锛︼几锛插湪鑳嗘眮娣ょН鍙婂叾鑽墿娌荤枟涓殑鐮旂┒杩涘睍 锛 锛 锛 锛戔垪 锛戔垪 寰愪繍娲 陰拫鎬濊揪 陰鏅 陰潕濠峰┓ 陰儭搴嗗崕 (锛?涓浗鑽澶у鑽闄㈥幀姹熻嫃 鍗椾含锛掞紤锛愶紣锛愶紮陰伙紥.鍗椾含甯傜浜屽崄涔濅腑瀛﹃幀姹熻嫃 鍗椾含锛掞紤锛愶紣锛愶紣) 鎽樿:浣撳唴鑳嗘眮鍦ㄧ敓鐞嗙姸鍐典笅浠ヨ倽鑲犲惊鐜殑鏂瑰紡澶勪簬鍔ㄦ€佸钩琛′腑陰€岃儐姹佸悎鎴愭垨娴佸姩闅滅灏嗗鑷磋儐姹佹筏绉幃 鑳嗘眮鐨勯噸瑕佺粍鎴愪箣涓€鏄儐姹侀吀陰硶灏奸叝锛 鍙椾綋(锛︼几锛?绛夋牳鍙椾綋鑳介€氳繃璋冩帶鑳嗘眮閰稿悎鎴愪唬璋㈤叾鍜岃儐姹侀吀杞繍铔嬬櫧璋 鑺傝儐姹侀吀鐨勫悎鎴愩€佽浆杩愬拰浠ｈ阿绛夎繃绋嬯幃 娉曞凹閰几 鍙椾綋鏄爺绌舵不鐤楄儐姹佹筏绉殑闈剁偣涔嬩竴陰櫎浜嗗ゥ璐濊儐閰哥瓑涓婂競鑽墿 澶栮幀涓€浜涗紶缁熶繚鑲濆埄鑳嗙殑涓嵂鎻愬彇鐗╀篃鏈夎皟鎺ф硶灏奸叝锛 鍙椾綋鐨勪綔鐢幃 鏈枃缁艰堪浜嗚繎骞存潵浠ユ硶灏奸叝锛 鍙椾綋鍦ㄨ儐姹佹筏 绉腑鐨勪綔鐢ㄤ互鍙婁互娉曞凹閰几 鍙椾綋涓洪澏鐐圭殑鑳嗘眮娣ょН娌荤枟鑽墿鐮旂┒杩涘睍陰 鍏抽敭璇岤鑳嗘眮閰戈幓鑳嗘眮娣ょН陰绘硶灏奸叝锛 鍙椾綋 锛 锛 锛 涓浘鍒嗙被鍙耳锛诧紩锛楋紩銆€ 鏂囩尞鏍囪瘑鐮?锛°€€ 鏂囩珷缂栧彿:锛掞紣锛欙紩 锛曪紦锛楋紩(锛掞紣锛戯紭)锛愶紦 锛愶紤锛栵紮 锛愶紣锛 锝勶綇锝堹锛戯紣.锛戯紦锛曪紣锛? 锝?锝冿綆锝嬶綁.锝婏綈锝?锛掞紣锛戯紭.锛愶紦.锛愶紤锛 锛诧綇锝岋絽 锝忥絾 锝傦綁锝岋絽 锝侊絻锝夛絼 锝庯綍锝冿綄锝咃絹锝 锝掞絽锝冿絽锝愶綌锝忥綊 锛︼几锛 锝夛綆 锝冿綀锝忥綄锝咃綋锝旓絹锝擄綁锝 锝侊綆锝 锝掞絽锝岋絹锝旓絽锝 锝愶綀锝侊綊锝嶏絹锝冿綇锝旓綀锝咃綊锝侊綈锝 锛 锛 锛 锛戔垪 锛戔垪 锛革嫉锛綁锝婏綁锝 陰吉锛╋肌锛姬锛筹綁锝勶絹 陰吉锛 锛綍锝 陰棘锛 锛达綁锝庯絿锝旓綁锝庯絿 陰绩锛碉急锝夛綆锝囷綀锝曪絹 (锛?锛筹絻锝堬綇锝忥綄 锝忥絾 锛帮綀锝侊綊锝嶏絹锝冿綑陰迹锝堬綁锝庯絹 锛帮綀锝侊綊锝嶏絹锝冿絽锝曪綌锝夛絻锝侊綄 锛碉綆锝夛綎锝咃綊锝擄綁锝旓綑陰籍锝侊綆锝婏綁锝庯絿 锛掞紤锛愶紣锛愶紮陰迹锝堬綁锝庯絹陰 锛?锛絹锝庯綂锝夛綆锝 锛綇.锛掞紮 锛綁锝囷綀 锛筹絻锝堬綇锝忥綄陰籍锝侊綆锝婏綁锝庯絿 锛掞紤锛愶紣锛愶紣陰迹锝堬綁锝庯絹) 锛★絺锝擄綌锝掞絹锝冿綌:锛╋綆 锝愶綀锝欙綋锝夛綇锝岋綇锝囷綁锝冿絹锝 锝冿綇锝庯絼锝夛綌锝夛綇锝庯綋陰絺锝夛綄锝 锝夛綋 锝勶綑锝庯絹锝嶏綁锝冿絹锝岋綄锝 锝傦絹锝岋絹锝庯絻锝咃絼 锝傦綑 锝旓綀锝 锝咃綆锝旓絽锝掞綇锝堬絽锝愶絹锝旓綁锝 锝冿綁锝掞絻锝曪綄锝侊綌锝夛綇锝 锝夛綆 锝旓綀锝 锝堬綍锝嶏絹锝庯綋陰 锝楋綀锝咃綊锝咃絹锝 锝傦綁锝岋絽 锝擄綑锝庯綌锝堬絽锝擄綁锝 锝勶綑锝擄絾锝曪綆锝冿綌锝夛綇锝 锝忥綊 锝傦綁锝岋絽锝嗭綄锝忥綏 锝勶綁锝擄綌锝曪綊锝傦絹锝庯絻锝 锝冿絹锝 锝冿絹锝曪綋锝 锝冿綀锝忥綄锝咃綋锝旓絹锝擄綁锝?锛綆锝 锝忥絾 锝旓綀锝 锝夛綅锝愶綇锝掞綌锝侊綆锝 锝冿綇锝嶏綈锝忥綆锝咃綆锝 锝忥絾 锝傦綁锝岋絽 锝夛綋 锝傦綁锝岋絽 锝侊絻锝夛絼 锝侊綆锝 锝庯綍锝冿綄锝咃絹锝 锝掞絽锝冿絽锝愶綌锝忥綊