过饱和度和温度对62氨基青霉烷酸生长晶习的影响.pdf

2005 年 5 月 　　 　化 　学 　工 　业 　与 　工 　程 第 22 卷 　第 3 期 　 May 2005 CHEMICAL 　INDUSTRY　AND 　EN GINEERIN G Vol . 22 　　No . 3 ( ) 　　文章编号 :1004 - 9533 2005 03 - 0157 - 04 过饱和度和温度对 6氨基青霉烷酸 生长晶习的影响 龚俊波 ,王静康 (天津大学化工学院 ,天津 300072) ( ) 摘要 :对于 6氨基青霉烷酸 简称 6APA 晶体在溶液中的生长 ,在不同物理化学环境下可得到不同 的晶习 ,试验考察了过饱和度以及温度对 6APA 生长晶习的影响 。通过测定 6APA 晶体结构 ,分析 6APA 晶体不同晶面的分子堆积 ,定性解释了过饱和度以及温度引起 6APA 生长晶习变化的原因 , 可为 6APA 生产工业放大提供了理论和试验依据 。 ( ) 关键词 :晶习;6氨基青霉烷酸 6APA ;过饱和度 ;温度 中图分类号 :TQ0261 　文献标识码 :A Effect of Supersaturation and Temperature on the Crystal Habits of 6Aminopenicillanic Acid GON G Junbo , WAN G Jingkang ( School of Chemical Engineering ,Tianj in University ,Tianj in 300072 ,China) Abstract :The habits of 6aminopenicillanic acid (6APA) were characterized for growth from special physical and chemical environment of solutions. The effects of supersaturations and temperatures on the habits of 6APA were investigated . The results were explored with 6APA crystal structure and 6APA molecule package in the crystal , which was measured by single crystal diffraction method . The study as theory and experimental foundation for the 6APA reactive crystallization process enlarger and design was put forward . Key words :crystal habit ;