中成药在孕妇中使用的安全性研究.docVIP

中成药在孕妇中使用的安全性研究 张瑞丽王景红苏爽梅娜郑金凤夏坤宗志勇 中国中医科学院望京医院药学部 摘要： 目的:编制孕妇安全使用中成药手册，为医师、药师提供用药参考。方法:对望京 医院200种中成药的说明书、2015版《中国药典》和2010版《临床用药须知》 屮孕妇用药信息的标注情况及其孕妇禁忌成分进行梳理、分析，挖掘屮成药在孕 妇用药中的安全隐患，初步提出孕妇安全使用中成药的建议。结果:200份中成 药说明书中有113份明确标注了有效孕妇用药信息，其中“孕妇禁用” 55种、 “孕妇慎用” 33种、“孕妇忌用” 25种;参考2015版《中国药典》和2010版《临 床用药须知》，增加孕妇禁用30种、孕妇慎用7种;通过对中成药所含孕妇禁忌 成分进行分析，增加孕妇禁用15种、孕妇慎用13种;筛选出38个孕妇使用相对 安全的品种。结论:200种常用中成药多是孕妇禁忌品种，在使用中有一定的安 全隐患，编制孕妇安全使用中成药手册，对提高孕妇使用中成药安全性，提升 药学服务质量具有重要意义。 关键词： 中成药;艇安全性研宂;药学服务; 作者简介：张瑞丽，女，主管药师;研究方向:临床药学;Tel: (010)E-mail:zhangrl_1985@126. com 作者简介：王景红，女，主任药师;研究方向：医院药学;Tel: (010)E-mail:wangjinghong2002@126. com 收稿日期：2017-06-15 基金：2016年北京药学会临床药学研究项目 Study on the safety of Chinese patent medicine used in pregnancy ZHANG Rui-li WANG Jing-hong SU Shuang MEI Na ZHENG Tin-feng XIA Kun ZONG Zhi-vong Department of Pharmacy， Wangjing Hospital of China Academy of Chinese Medical Sciences; Abstract： Objective: To draw up a Chinese patent medicine (C1)M) manual for pregnancy and provide medication safety information to physicians and pharmacists. Methods: We investigated and analyzed drug information for pregnancy from instructions, Chinese Pharmacopoeia (2015 Edition)，and Cl inical Application Guidelines (2010 edition) of 200 CPMs. Contraindications and potential safety problems for pregnancy of these CPMs were explored, and relevant medication suggestions were made. Results: Drug information for pregnancy were marked in the instructions in 113 CPMs, where ’ prohibited’ were marked with 55 CPMs, ’caution’ were marked with 33 CPMs, and ’contraindication’ were marked with 25 CPMs. According to Chinese Pharmacopoeia (2015 Edition) and Clinical Application Guidelines (2010 edition)，30 CPMs were marked as administrated with prohibited’ and 7 CPM were marked as ’ administrated with caution’ ? Furthermore, 15 CPMs were marked as ’prohibited’ and 13 CPM were marked as ’caution’ due to containing contraindicated composition for pregnancy. Thirty eight CPMs were selected as relativ