乳腺超声弹性成像联合血清MCP1含量测定在乳腺良恶性肿瘤鉴别诊断中的作用.docVIP

乳腺超声弹性成像联合血清MCP-1含量 测定在乳腺良恶性肿瘤鉴别诊断中的作 吕明丽杨饪曾敏牛建梅IP 吕明丽杨饪曾敏牛建梅 IP 上海交通大学医学院附属国际和平妇幼保健院超声 : 目的:探讨乳腺超声弹性成像联合血清人单核细胞趋化因子1 (monocyte chemoattractant protein 1, MCP-1)含量测定在乳腺良恶性肿瘤鉴别诊断1+1的 作用。方法:选取2015年1—6月就诊于上海交通大学医学院附属国际和平妇幼 保健院乳腺科的患者60例，行常规二维超声和压迫式声弹性成像，计算弹性应 变率(strain ratio, SR)。Luminex液相芯片测定患者术前血清MCPT水平。 以病理结果为金标准，评价上述两种方法单独及联用的诊断效能。结果:乳腺超 声弹性在截断点为4. 87时，灵敏度为83. 33%,特异度为70.81%。血清MCP-1 测定截断点为45. 6 pg/m L时，灵敏度为100. 0%,特异度为91.7%。两种方法联 用后其受试者工作特征(receiver operating characteristic, ROC)曲线的曲 线下面积为0.99,与单独使用乳腺弹性成像相比，差异有统计学意义 (P=0. 002 5) o乳腺恶性肿瘤弹性成像SR值与血清MCP-1水平呈正相关 (r=0. 732, P0.01)。结论:乳腺超声弹性与血清MCP-1联用可大大提高对乳腺 良恶性肿瘤的鉴别诊断效能，具有一定的临床应用价值。 关键词： 乳腺肿瘤;压迫式弹性成像;单核细胞趋化因子1； 牛建梅，E~mai 1 : ni ujm5@l26. com 2017-04-15 基金：中国福利会国际和平妇幼保健院优秀青年培育计划 Compression elastography and serum MCP-1 level in differential diagnosis of benign and malignant breast tumors LV Mingli YANG Yu ZENG Min NIU Jianmei Department of Ultrasonography, International Peace Maternity Child Hea1th Hospital, Shanghai Jiao Tong University School of Medicine; Abstract： Objective: To evaluate the roles of compression elastography and serum monocyte chemoattractant protein 1 (MCP-1) level in the differential diagnosis of begin and malignant breast tumors. Methods: A total of 60 patienls with 1 iver lesions were selected from International Peace Mater nity Child Ilea 1th Hosp it al, Sha nghai Jiao Tong Uni versity School of Medicine from January to June 2 ol6. They underwent the convcntional ultrasound and compression elastography examinations and strain ratio (SR) was obtained. Luminex liquid chip technology was used to analyze the level of MCP-1 in serum. The two methods alone and in comb in at ion were appl ied in this study. The pathological resuIts were set as the gold standard and used to evaluate the diagnosis efficiency in differential diagnosing benign and malignant breast tumors. Results: With the cutoff value of SR at 4.87, the sensitivity and specificity of compression elastography in the diagnosis of mal igna