激活TRPV1和PPARδ对高血压鼠肾脏氧化应激和钠葡萄糖转运体2的作用-内科学(内分泌与代谢病)专业论文.docxVIP

第三 第三军医大学硕士学位论文 万方数据 万方数据 英文缩写一览表 英文缩写 英文全称 中文全称 TRPV1 transient receptor potential vanilloid subfamily member1 瞬时受体电位通道香草醛亚家族 1 型 eNOS endothelial nitric oxide synthase 内皮型一氧化氮合酶 NO nitric oxide 一氧化氮 DOCA Deoxycortone Acetate 脱氧皮质酮 NOS phosphorylated eNOS 磷酸化内皮型一氧化氮合酶 ROS reactive oxygen species 活性氧簇 DHE dihydroethidium 二氢乙锭 DAF-2DA 4,5-diaminofluorescein diacetate 4,5-二氨基乙酰乙酸荧光素 UCP2 Uncoupling proteins 2 解偶联蛋白 2 PPARδ peroxisome proliferator-activated 过氧化物酶体增殖物激活受体δ SGLT2 sodium glucose co-transporter2 钠-葡萄糖共转运体 2 3 Effects of TRPV1/PPAR delta Activation on Renal Oxidative Stress Damage and Na-Glucose Transporter 2 Abstract Background and objective: With the development of economy and society, hypertension has become one of the most common chronic diseases in the world. Hypertension is the main cause of stroke, kidney failure and other serious disease of cardio-cerebrovascular disease. The World Health Organization (WHO) reported that hypertension is a leading cause of death of cardiovascular disease worldwide. High blood pressure has become a major health problem damaging our life and health, and its prevention and control has prominent significance and value. Genetic and environmental factors are associated with the pathogenesis of hypertension. Studies show that dietary factors such as high-calorie food, the low- potassium and high-sodium food affect the development of hypertension importantly. A large number of studies show that high salt intake leads to blood pressure increase. Between salt intake and blood pressure has a clear dose-effect relationship, and reducing salt intake can prevent hypertension and cardiovascular disease significantly. More effective dietary intervention has important significance to improve hypertension and cardiovascular disease induced by the high-salt diet. Transient Receptor Potential Vanilloid 1(TRPV1) cation channel is a polymodel nonselective cation channel, and expresses in sensory neurons system and also presents in nonne