课件：第章淋巴细胞和淋巴细胞.ppt

CD5 B Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y IgM B-1细胞的主要生物学功能 -主要识别TI-2抗原的多糖类物质，如荚膜多糖，聚合鞭毛素等； - 参与对多种细菌（尤其体腔中）的抗感染免疫； - 产生低亲和力IgM类的生理性自身抗体，参与对衰老、蜕变自身细胞的清除； - 通过产生IgM类自身抗体参与某些自身免疫病的发生 B Mature B-2 B cell B-2 细胞的主要生物学功能 - 参与体液免疫应答： BC+Ag?在Th辅助下? 活化增殖 ?分化浆细胞? 产生高亲和力抗体 - 抗原提呈： BC用BCR摄取Ag ? 处理肽+MHCII ? 提呈抗原给CD4T细胞，提供协同信号 - 免疫调节： 活化BC产生多种细胞因子，参与免疫调节 Y Y Y Y Y Y IgG B-1细胞和B-2细胞的异同 T B 抗原受体 TCR BCR 复合受体带ITAM成分 CD3 Ig? Ig? 辅助受体 CD4或CD8 CD19/21/81/225 协同刺激分子 CD28 CD40 配体 B7 CD40L 识别Ag形式 MHC-抗原肽 游离 表位性质 线性 构象/线性 1 2 THANK YOU SUCCESS * * 可编辑 * There is another molecule, called CTLA-4. Tcell receive the both signals from TCR and CD28 , then being completely activated which leads to expression of CTLA-4. CTLA-4 can also binds to B7 molecules with about 20 times higher affinity than does CD28, so CTLA4 can occupy most or all of the B7 molecules, then effectively inactivate T cells and shut down the immune response. delivers an inhibitory signal to the activated T cell. an inhibitory receptor for B7 molecules. Naive T cells express CD28, which delivers a co-stimulatory signal on binding B7 molecules (left panel), thereby driving the activation and expansion of T cells that encounter specific antigen presented by an antigen-presenting cell. Once activated, T cells express increased levels of CTLA-4 (CD152; right panel). CTLA-4 has a higher affinity for B7 molecules than does CD28 and thus However, (Fig. 8.12). This makes the activated progeny of a naive T cell less sensitive to stimulation by the antigen-presenting cell and limits the amount of an autocrine T-cell growth factor, interleukin-2 (IL-2), that is produced. Thus, binding of CTLA-4 to B7 molecules is essential for limiting the proliferative response of activated T cells to antigen and B7. * B1：分布在腹腔、胸腔和肠壁固有层。 * （2）按CD4和CD8