混合价态钨基纳米材料的制备及在光热疗法方面的应用-生物医学工程专业论文.docxVIP

哈尔滨工业大学工学硕士学位论文 哈尔滨工业大学工学硕士学位论文 万方数据 万方数据 关键词：混合价态氧化钨；W18O49；溶剂热法；光热治疗；热疗“第二窗口” II - Abstract Recently, photothermal therapy (PTT), which uses photoabsorbing agents for localized heating tumor under near-infrared light irradiation, is receiving increased attentions as a promising treatment alternative to conventional approaches for achieving the specific elimination of tumor with minimal invasion and high selectivity since its therapeutic effect happens only at the tumor site where both light-absorbent and localized laser radiation coexist. Effective implementation of PTT is inseparable from the long wavelength near-infrared (NIR) laser and PTT agents with promoted absorption at the site coincided with wavelength of NIR laser. Although many kinds of nanomaterials with plasmon resonance are currently used as PTT agents, synthesitic method for these nanomaterials is too complexed and hard to realize morphology- controllable synthesis. In addition, in terms of NIR absorptive properties, they have several unavoidable shortcomings such as narrow absorption spectrum, weak absorptivity and light stability, as well as irresponsive to the second NIR window between 1000 and 1400 nm where has been proven to possess deeper tissue penetration ability. Therefore, it is highly desirable to develop new NIR light nanoabsorbents with strong absorption in the range of 1000-1400 nm and controllable nanostructures.. In this paper, a series tungsten-oxide nanostructures, such as nanospheres, nanowires, columnar nano-brush, spindle nanoparticles and so forth, have been faricated under solvothermal condition by employing different combination of tungsten precursors and organic alcohols, as well as altering molar ratio between them. It has been found that these nanomaterials are of W18O49 nature and all show strong optical absorption in NIR range from 1000 to 1400 nm. Through the comprehensive consideration of the morphology and performance of synthesized nanoparticles, this thesis selected