急性脑梗死患者血清高敏C-反应蛋白水平与脑水肿严重程度的相关性分析-内科学专业论文.docxVIP

致 (P0.05) 。 血 清 Hs-CRP 水 平 与 脑 水 肿 的 严 重 程 度 呈 正 相 关 (P0.05)。 结论：Hs-CRP 可能与 ACI 患者脑水肿的发生、发展过程 密切相关，对脑水肿的严重程度和病情判断有一定的临床指导价值， 有望成为检测脑水肿的一项新指标。 关键词：急性脑梗死；脑水肿；高敏 C-反应蛋白；脑电阻抗； 扰动系数 ABSTRACT Objective: To observe the correlation between the change of serum high sensitivity C-reactive protein and the transformation, development and its clinical implication of cerebral edema in patients with acute cerebral infarction. Methods: According to NIH Stroke Scale (NIHSS) standards of grading 60 patients with ACI were divided into three groups. Mild ACI group was scored from 0-4 points, moderate ACI group was scored from 4-15 points and severe group scored more than 15 points. The serum Hs-CRP level of 60 patients with ACI were determined continuously on the second day, the third, the fifth and seventh day after hospitalization. Meanwhile, 60 patients with ACI were detected the change of cerebral electrical impedance turbulence coefficient of lesion cerebral hemisphere by BORN-BE-Ⅱ non-invasive brain edema monitor. 40 healthy subjects was included as control group. Results: Hs-CRP level in ACI group were significant higher than control group on the second day, the third day, the fifth day and seventh day after hospitalization. The level on the third day was higher than the second day, reaching a peak on the fifth day and decreasing on the seventh day. The level of severe group was higher than moderate group, and moderate group was higher than mild group. Differences reached statistical significance (P0.01, P0.05). The cerebral electrical impedance turbulence coefficient of lesion hemisphere in ACI group were higher than normal amount after hospitalization. It was higher on the third day than the second day, reaching a peak on the fifth day and decreasing on the seventh day. The level of severe group was higher than moderate group, and moderate group was higher than mild group. Differences reached statistical significance (P0.05). The level of serum Hs-CRP was positively correlate