积雪甙瘢痕内注射治疗病理性瘢痕的临床研究-外科学(整形外科)专业论文.docxVIP

y-,·618351中文摘要积雪甙瘢痕内注射治疗病理性瘢痕的临床研究中文摘要目的观察积雪甙注射剂治疗病理性瘢痕的临床疗效和安全性。方法采用随机平行对照的试验方法，将72例患者随机分为试验组和对照组。 设积雪甙注射剂组为试验组，应用积雪甙注射剂瘢痕内注射，每周一次，连续应用 3月。设曲安奈德注射剂组为对照组，应用曲安奈德注射剂瘢痕内注射，每2周一 次，连续应用3月。2组结果应用SPSSll．5统计软件以t检验和x 2检验的方法进行 统计学处理，比较2组治愈率、好转率的差异，探讨积雪甙注射剂治疗病理性瘢痕 的临床疗效。结果临床试验观察表明，治疗1月时，曲安奈德注射剂组有效率优于积雪甙注射剂组，差别有显著统计学意义(p0．01)；2组治愈率无显著性差异(pO．05)。 3月和6月时，2组治愈率、有效率均无显著性差异(口O．05)。12月后，2组治愈 率、有效率无显著性差异(pO．05)。在本研究中，积雪甙注射剂组未出现不良反应。结论积雪甙注射剂是一种安全有效治疗病理性瘢痕的药物。关键词积雪甙；注劓；瘢痕研究生：董子迎(整形外科)导师：．吴延芳茎苎塑矍一一一CL l N I CALSTUDYONTHETREATMENTOFABNORMALSCARSW I THASIATICOSlDEINJECTlONlNTOABNORMALSCARSABSTRACTObject i veInordertofind a new drugtotreat abnormal scars．We choose asiaticoside injection and evaluate the therapeutic effect and safetyinthe treatmentof abnormal SCarS with it．Methods A clinical trial was conducted in randomized and parallel—control method． Seventy-two patients witll abnormal scars were randomly divided into trial and control groups．The trial group were treated with asiaticoside injection every week for three months consecutively．The control group were treated with Triamcinolone Acetonide injection every two weeks for three months consecutively．Using methods of t-test and X2_test．t11e results were statistically analyzed with the software of SPSS 1 1．5 to compare the therapeutic effect between the trial and control groups．Resu I ts After 1 month，the effective rate of the control group was superior to the trial group and there was significant difference between them 0O．01)；at the same time， there was no significant difference between the cure rate of trial and control groups (p0．05)．After 3 months and 6 months，in the cure rate and effective rate，there was nosignificantdifferencebetweenthecure rate oftrial and control groups(pO，05)．1 2months later，there was no significant difference between the cure rate oftrial and control groups in the cure rate and effective rate(p0．05)．Ciinical observation showed that no side—effect was found in the trial group．Cone I US i onAsiaticoside in