环境响应性壳交联胶束的制备及研究-材料物理与化学专业论文.docxVIP

东华大学术型硕士学位论文 东华大学术型硕士学位论文 V V [1，3]-二氧戊环，其中后面两种交联剂分别具有双硫键和原酸酯结构。 最后将这三种二叠氮化物作为交联剂加入到由此嵌段聚合物组装的 胶束溶液中，在铜盐催化作用下通过点击化学制备得到了具有环境响 应性的壳交联胶束，并对聚合物胶束的粒径、粒径分布和降解性能进 行了研究。 关键词： pH 敏感型聚合物；环境响应性；壳交联胶束；点击化学 II II Abstract In the past decade, nanoparticles and its application in drug delivery system have attracted great attention and became a hot topic, because they have passive targeting ability in tumor tissue which has the enhanced permeation and retention effect (EPR effect). Due to the long blood circulation, improved water solubility, and facile integration of functionalities, the tumor microenvironments-responsive polymeric micelles as novel anticancer drug vectors show the great potential application. The disulfide bond is reduction-sensitive and is prone to rapid cleavage at a time scale from minutes to hours under a reductive environment. And the structure of ortho esters have the acid-sensitive property, it will be degradable under weakly acidic conditions. Since the reduction in tumor cells is much higher than in body circulation and extracellular milieus, and the pH in tumor cells is much lower, so the micelle based on polymer which contain the disulfide bond and the structure of ortho esters have the great potential to be used as the drug carriers to achieve the controlled-release of the drug. The major works of this paper are: A well-defined poly[(ethylene glycol)-block -2-(dimethylamino)ethyl methacrylate-block-2-(diethylamino) methacrylate] (PEG-b-DMA- b-DEA) triblock copolymer was synthesized via atom transfer radical polymerization (ATRP) by successively polymerization of DMA and DEA monomers using a PEG-based macroinitiator, and obtained copolymer was then converted to be PEG-b-P(DMA-co-QDMA)-b-PDEA copolymer with “clickable” moieties in the middle block by the quaternization with propargyl bromide. Then the cross-linkers 1,6-bisazidehexane, bis-(azidoethyl)disul?de which contains the reduction-sensitive disulfide bond and 4-Azidomethyl-2-