麻杏止咳合剂治疗小儿肺炎（痰热闭肺型）的实验和临床研究-中医儿科临床专业毕业论文.docxVIP

MCItM MCItM M舣ing Cough ReliefMixture 麻杏止咳合剂 EQK Ertong Qifei Koufuye 儿童清肺口服液 O．9％SCI Sodium Chloride埘ecfion O．9％氯化钠注射液 RCCRS Robitussin Cold＆Cough ReliefSolution 惠菲宁抗感冒止咳药 删 Ambroxol Hydrochloride Injection 沐舒坦 中文摘要中文摘要 中文摘要 中文摘要 日的：从实验、临床和理论方面对麻杏止咳合剂治疗小儿肺炎(痰热闭肺型)的疗 效和作用机理进行系统观察和研究。 方法：实验研究：选用清洁级ICR小白鼠，灌胃给药，治疗组给予麻杏止咳合剂， 对照组分别给予儿童清肺口服液、惠菲宁抗感冒止咳药、沐舒坦及生理盐水，通过氨水 引咳法观察小鼠咳嗽潜伏期和2min内小鼠咳嗽次数，研究麻杏止咳合剂对小鼠的止咳 作用：通过酚红排泄法观察小鼠气管酚红排泌量，研究麻杏止咳合剂对小鼠的祛痰作用。 临床研究：将90例肺炎(痰热闭肺型)患儿随机分为2组，治疗组60例，对照组30 例。治疗组给予麻杏止咳合剂，对照组D月EtJL童清肺口服液，用药两周。两组用药期间， 均使用西药(头孢类)抗感染治疗。观察患几症状、体征和实验室检查的变化。 结果：实验研究表明三个剂量的麻杏止咳合剂均能明显延长氨水致小鼠咳嗽的潜伏 期，减少咳嗽次数。且作用强度与剂量呈正比，具有很好的镇咳作用；大、中剂量的麻杏 止咳合剂均能明显增加小鼠气管酚红排泌量，具有祛痰作用。临床研究结果显示：治疗组 总有效率与对照组比较有显著性差异，且治疗组退热、祛痰、平喘、消除肺部眵音时间 均优于对照组，未见明显不良反应。 关键词肺炎；临床研究；麻杏止咳合剂：实验研究 2 2 摩杏止咳台剩治疗小儿肺炎痰热明肺型)的实验和临废研究 Abstract Object：To investigate the curative effect on Maxiug Cough Relief Mixture(MCRM) treating pneumonia and its mechanism by doing some experimental and clinical researches． Method：Experimental Research：There ale two experiments on white mice．One is to confmn whether MCRM can relieve cough by using NH3 incenting cough method，the other is tO confirm whether MCRM call alleviate spit by using phenolphthalein discharged method． Sixty mice were divided into six groups randomly．And each group were given different drugs which were MCRM(much dose)，MCRM(middle dose)，MCRM(1ittle dose)，Ertong Qifei Koufuye正QK)，0．9％Sodium Chloride珂ection(scD，Robitussin ColdCough Relief Solution(RCCRS)or Ambroxol Hydrochloride Iniiection(AHl)．Test the cough relief utility of these drugs by investigating how long the mice begin to cough and how many times they cough in two minutes．And test their spit relief utility by investigating how much phenolp|：lthalein are discharged from windpipes of mice．ainical Research：90 children who suffered from pneumonia were divided into two groups randomly As one group 60 children were given MCRM for two weeks，the other