血脂异常患者HDLC、甲状腺激素与冠心病的相关性分析.docVIP

血脂异常患者HDL?C、甲状腺激素与冠心病的相关性分析 叶丽丽，阮云军 （广州军区总医院心血管内科，广东广州510010） 摘要：【目的】研究长期规范降脂治疗的血脂异常人群高密度脂蛋白胆固醇（HDL?C）、促 甲状腺素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）水平并分析HDL?C、 TSH、FT3、FT4与冠心病的相关性。【方法】收集2014年4月至2017年04月于广州军区 总医院心血管内科住院经冠状动脉造影明确诊断为冠心病的血脂界常患者共152例，另外收 集同期我院心内科住院排除了冠心病的血脂异常人群105例。入院后分别收集两组血清样本 行血脂水平和甲状腺功能检测。【结果】冠心病组和对照组的HDL?C、TSH、FT3、FT4水 平比较，HDL?C、FT3差异具有统计学意义（PvO.05）；冠心病组及对照组TSH、FT3、FT4 与HDL-C均无明显相关（P0.05）；在对照组中，TSH、FT4与TG、TSH与TC有相关性, 差异具有统计学意义（PV0.05）。【结论】长期规范降脂治疗的冠心病患者HDL?C、FT3水 平均下降，提示HDL-C可能可以减少、延缓冠心病的发生和发展，而甲减可能是冠心病的 危险因素之一。 关键词：冠心病；血脂异常；HDL?C；甲状腺激素 Correlation Analysis between HDL-C Thyroid Hormone Levels and CoronaryHeart Disease in Patients with Dyslipidemia Ye Lili,Ruan Yunjun (Department of Cardiology,Military General Hospital of Guangzhou Command,Guangzhou 510010,China) Abstract： [Objective] The aim of this study was to investigate the level of HDL-C、TSH FT3、 FT4 and HDL-C in patients with dyslipidemia who have long-term lipid-lowering therapy and the correlation between HDL-C、TSH、FT3、FT4 and coronary heart disease.【Methods ]We collected 152 cases of dyslipidemia patient diagnosed with coronary artery disease by coronary angiography in Military General Hospital of Guangzhou Command from 2014-04 to 2017-04 and collected 105 cases of dyslipidemia patient diagnosed without coronary artery disease. The serum samples in two groups were collected to detect the serum lipid levels and thyroid function.【Results】 Compared with the control group, the difference of HDL-C and FT3 from coronary heart disease groupt was statistically significant (P 0.05) ? However, in patients with CHD and control group,there was no significant coiTelation (P 0.05) betweenTSH FT3、FT4 and HDL-C. In control group, TSH^ FT4 correlated with TG、TSH correlated with TC, the difference was statistically significant/P 0.05)?【Conclusions]In patients with dyslipidemia and coronary heart disease, the level of HDL-C and FT3 decreased, which point out that HDL-C may defer the development of coronary hea