卵巢早衰与PGRMC1基因的相关性研究及中药治疗规律分析-中西医结合临床专业论文.docxVIP

山东大学博‘{二学位论文CATALoGUE 山东大学博‘{二学位论文 CATALoGUE Abstract(in Chinese)．．．．． ．．．．．． ．．． ．．． ．．． ．．．． ．． ．．． ．．． ．．．． 1 AbstractT(in English) ． ．．．． ．．．．． ．．． ．．．．．．． ．．．．．．． ．．．．．．． ． ．．．．． ．．．． ．． ．．．． 5 Abbreviations ． ．．．．．．． ．．．．． ．． ．．．． ．． ． ．．． ． ．．．．． 。．．．．10 Introduction 1 1 Part I：A Correlation Study ofPremature Ovarian Failure and Progesterone Receptor Membrance Componem 1 1 8 Materials and methods ． ．．． ．．． ．．．． ． ．．．． ．， ．．． ，．， ． ． 18 Result ．． ．． ． ．． ． ．． ．． ．． ．． ．．．． ．． ． ．．26 Discussion． ．．．．． ． ．． ．． ．． ．． ．．． ． ．．．． ．．． ． ．． ． 27 Conclusion ． ．． ．．． ． ．． ．．29 PartlI： An Analysis of the Traditional Chinese Medication Regularity for Treating Premature Ovarian Failure Based on the Dictionary of Chinese Medicine Prescriptions ． ． 30 Materials and methods 一30 ResuIt ．31 Discussion 42 Conclusion ．．．． ．． ． ．．． ．．． ．49 Tables and Figures ． ．． ． ．．．． ．．．． ．．． ．． ． ． ．． ．．． ．．51 Referenees．．．．．．．．．．．， ． ．． ，． ． ．． ． ．．， ．．． ．．． ．． ． ．．．． ．． ．．． ． ．． ，．54 Acknowledgement ． ． ． ．． ．． ． ． ．． ．．．．． ． ．．． ．． ． ．．．．． ．．．．．．．．．62 Published papers．．． ．。． ．，，．．． ．． 。，，． ． ．． 一 ． ．．。。 ． ．。． ， ．．。 63 Paper evaluation table．．． ．．．． ．．．． ． ． ．．． ． ．．． ．． ．． ． ． ．．． ．．． ．．．64 English paper I ．65 English paper II ．． ．． ． ．．． ．． ．． ．．． 74 万方数据 山东人学博一j学位论义卵巢早衰与PGRNCl基因的相关性研究及中药治疗规律分 山东人学博一j学位论义 卵巢早衰与PGRNCl基因的相关性研究及中药治疗规律分 析 中文摘要 第一部分卵巢早衰与PGRNCl基因的相关性研究 研究背景 卵巢早衰(POF)病因尚不明确，约30％的卵巢POF患者发病与 遗传因素有关，颗粒细胞凋亡致卵泡闭锁过多是卵巢早衰发病的一个 重要机制。越来越多的参与卵泡发育过程的基因被证实与POF发病相 关，如GDF9、FOX03、NOBOX、FIGLA、FMRl、FMR2、BMPl