两亲性官能团化聚己内酯聚合物合成以及表征-高分子化学与物理专业论文.docxVIP

湘潭大学硕士学位论文 湘潭大学硕士学位论文 Ⅱ Ⅱ Abstract Hydrophobic aliphatic polyesters such as poly(L-lactide) (PLA), polyglycolide (PGA) and poly(?-caprolactone) (PCL) are of great important synthetic biomaterials for biomedical applications. These materials possess exceptional biocompatibility; biodegradability; low immunogenicity and good mechanical properties which facilitated their value as components of surgical suture, skeleton fixation, tissue engneering and drug delivery systems. Among these, PCL especially has been widely explored due to its good compatibility and neutral degradation end products which do not alter the pH of the degradation medium. However, the biodegradation rates of PCL is difficult to control due to its hydrophobicity and crystallinity. Therefore, preparation of modifying PCL is of great necessity. In the present study, pendent functional amphiphilic aliphatic polyester was prepared from methoxy poly(ethylene glycol) (MPEG) and functional ε-caprolactone monomer, which was obtained by ring-opening polymerization. The main contents were as follows: 1．Amphiphilic biodegradable diblock copolymer bearing aldehyde groups was synthesized by the combination of ring-opening polymerization (ROP) and thio-bromo “click” chemistry. The free aldehyde groups on the copolymer were reacted with hydrophobic payloads (p-methoxylaniline as a model drug) via benzoic-imine linker, which was responsive to pH change. In addition, we also investigated the model drug release profiles. 1H NMR、FT-IR、GPC、UV-Vis、SFS、 DLS and AFM were used to investigate. 2．γ-(acetic acid tert-butyl ester)-ε-caprolactone monomer (γAABεCL) was synthesized. Amphiphilic aliphatic polyesters, methoxy-poly(ethylene-glycol)-block- poly(γ- (acetic acid tert-butyl ester)-ε-caprolactone) (MPEG-block-P(γAABεCL)), were prepared by ring-opening polymerization using stannous(II) 2-ethylhexanoate (Sn(Oct)2 ) as catalyst and mPEG as macroinitiator. These products were characterized by 1H NMR、13C NMR、FT-IR