两类新型大分子配体及其钆、铁络合物的合成和弛豫性能研究-有机化学专业论文.docxVIP

华中科技大学硕士学位论文摘要 华中科技大学硕士学位论文 摘要 磁共振成像(MRI)是近年来迅速发展的医学影像新技术，MRI造影剂是 这一技术的组成部分。MRI造影剂是用来增强J下常组织之间、『F常与病变组织 之|白J的磁共振信号对比度的一类化学试剂。合成新型的造影剂对磁共振成像技术 的发展具有十分重要的意义。本文介绍了一系列新型的含酯基、酰胺基配体及其 Gd3+、Fe”配合物的合成。为了获得含有孤对电子的氮、氧原子大分子配体，我 们选用了含有这些共聚单体。 f本文通过羟基羧酸与脂肪族二元胺在高温下反应得到四种脂肪族酰胺二元 醇，由Y．丁内酯与脂肪族二元胺反应得到二种脂肪族酰胺二元醇。通过二乙酰 三胺五乙酸双酸酐与脂肪族酰胺二元醇共聚得到了主链中含有酯基、酰胺基的大 分子配体．其与Od3+、Fe”配合得到了水溶性线形大分子配合物。乙二胶四乙酸 单酸酐与脂肪族酰胺二元醇反应得到了含有两个配位中一心的新型配体，其与 Gd3+配位得到了双核顺磁性水溶性造影剂。又足一 ／ 一 表征了所有配体及其配合物的化学结构，并测试了这些配合物的纵向弛豫时 IuJ(T1)。计算了它们的弛豫效能(RI)。结果表明，这些配合物的弛豫效能都比 小分子配合物强，并且我们发现二倍体配合物的弛豫效能是Gd．DTPA的二倍甚 、 至更强。大分子Fe”配合物的弛豫效能比DTPA—Fe3+强。1只一 关键i司： 脂肪族酰胺二元醇} 二倍体配体配合物7线形大分子配体岁 磁共振成V啾陛水溶性造影剂}蹩堕二受屯 华中科技大学硕士学位论文Abstract 华中科技大学硕士学位论文 Abstract 0nr aim in this work is to synthesize new series of gadolinium and iron copolymeric chelates containing ester．，amide，and chelating groups．．Co-．monomers have been chosen in order lo obtain polymers containing nitrogen and earboxylate oxygen atoms that Call play a role of electron donors in the coordination sphere of complexes． Four Amido．一diols have been synthesized t y the reaction of hydroxhcarboxylic acids with aliphafic diamines at high temperature and two amido--dioles have been synthesized by reacting 7-butyrlactone with aliphatic diamines in the presence of isopropanol as reaction media． The polycondensa“on of diethyJenepentaace“c acid dianhydride with amido．-diols was investigated in order to obtain new complexing agents bearing aminoacetic，ester．，and amide groups along with the oligomer chain．Synthesis conditions have been studied to get linear water-．soluble polymers which can form complexes with Gd (IIF) and Fe 1／m)．The polycondensation of Ethylenediamintetraacetic acid mono·．anhydride with amido-dims was also investigated in order to develop dimers that can be used to synthesize binuclear gadolinium complexes consisting of an amido-diol linkc r that joins two EDTA segments(Gd—Dimer．·Gm． All compkxes synthesized in our work were used during the measurements of longitudin