磷酸酯化聚乙烯醇的制备及其体外模拟生物矿化研究-高分子化学与物理专业论文.docxVIP

华 华 中 科 技 大 学 硕 士 学 位 论 文 Ⅱ Ⅱ Abstract Biomineralization is an extremely delicate process which the organic matrix involved in throughout. In this process, the carbonic acid, phosphoric acid, etc. possessing negatively charged groups in the macromolecular matrix have the function of concentrating calcium ions, adjusting mineral nucleation and growth by electrostatic interaction. As a commonly used water-soluble polymer, polyvinyl alcohol (PVA) has been widely used in biomaterials. This article will focus on its derivatives Phosphate polyvinyl alcohol (PPVA), and prepare a series of PPVA with different phosphorus content as well as PPVA / hydroxyapatite composite porous hydrogel. This may be expected to be used for bone tissue repair. Two methods have been used for obtaining PVA with different phosphation degrees. A higher degree of esterification which was more than 20% of PPVA can be achieved when using DMF instead of water as solvent reaction system. The viscosity and the tensile strength of the resultant PPVA both reduced when the degree of esterification increasing. It was to be found that PPVA films with the degree of esterification had mineralized by the change of mass, PH, calcium and phosphorus content, XRD, SEM. The conclusion was the extent of this mineralization increased with an increasing of the degree of esterification, and the PVA film did not mineralized almost. The EDX spectrum shows the calcium phosphate molar ratio of formed inorganics was 1.57 which was close to 1.67 belonging to hydroxyapatite. In addition, a needle-like HA obtained which was about 40-60 nm and was close to the size of HA in the mature bone tissue in situ synthesis in the presence of PPVA. When adding the surfactant OP and rapidly stirring in advance, a more than 90% moisture Ⅲ Ⅲ content along with a certain mechanical strength of biodegradable PPVA/HA porous composite was prepared. This gel material has the potential to become a new bone tissue repair material. Keyw