利培酮鼻用凝胶剂的制备及其体内药动学评价-药剂学专业论文.docxVIP

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利培酮鼻用凝胶剂的制备及其体内药动学评价-药剂学专业论文.docx

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万方数据万方数据目录中文摘要································································································································（· 1）英文摘要································································································································（· 3）正文································································································································（· 6）前言································································································································（· 6）第一章利培酮鼻用凝胶剂的处方前研究 1 试药与仪器·······················································································································（8） 2 方法与结果·······················································································································（8） 2.1 利培酮 HPLC 含量测定方法的建立············································································（· 2.2 pH 值对利培酮溶液化学稳定性的影响······································································（· 8） 12） 2.3 pH 值对利培酮溶解度的影响·····················································································（13） 2.4 利培酮在部分有机溶剂中溶解度的测定··································································（13） 2.5 利培酮与两种 β-CD 衍生物包合作用的考察····························································（· 2.6 利培酮与两种 β-CD 衍生物相溶解度的测定·····························································（· 2.7 利培酮-HP-β-CD 包合物的制备及性质研究·····························································（· 14） 15） 17） 2.8 利培酮油水分配系数的测定······················································································（20） 3 本章小结··························································································································（22）第二章利培酮鼻用凝胶剂的处方与制备工艺及质量评价 1 试药与仪器······························································································