课件：ESR突变与芙仕得foraroval.pptxVIP

ESR1与内分泌治疗仅供医疗专业人士参考??医学审批编号419.616,022目录内分泌药物作用机制ESR1突变与内分泌药物耐药ESR1突变与乳腺癌治疗ER结构及作用机制E2-已调节 (构象改变)通过磷酸化调节ER结构LBDAF2AF1在雌激素反应部位与DNA相互作用1. CK Osborne et al. British Journal of Cancer (2004) 90(Suppl 1), S2–S62. Peter Schmid presented at Fulvestrant 500mg launch meeting in Shanghai 2015.AF2EAF2EAF1AF1内分泌治疗原则雌二醇ECo-Repressor 2转录Co-activator 2AF2RNA-Poly IAF2EAF2EREAF1ERE 共活化因子1AF1HSP90Co-Repressor 1AF11. CK Osborne et al. British Journal of Cancer (2004) 90(Suppl 1), S2–S62. Peter Schmid presented at Fulvestrant 500mg launch meeting in Shanghai 2015.ERE内分泌药物作用机制SERD氟维司群SERM他莫昔芬雌激素EETEREEREERE绝经前: