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2006 26 Vol. 26, 2006
12 , Chinese Journal of Organic Chemistry No. 12,
· ·
a a a a *,a,b
(a 361005)
(b 100084)
, , ,
. ,
, , , ,
.
; ; ; ;
Synthesis, Spectral Characterization and Biological Activities of
Phosphoryl Amino Acid Esters
CAI, Yi-Mina GAO, Xianga HUANG, Xian-Tonga
WANG, Tong-Jiana ZHAO, Yu-Fen*,a,b
a
( Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry,
Xiamen University , Xiamen 361005 )
(b Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education,
Department of Chemistry, Tsinghua University, Beijing 100084)
Abstract Phosphoryl amino acids and phosphoryl amino acid esters, as phosphorus analogs of amino acid,
have attracted much attention because they show wide biological activities. In this paper, the title com-
pounds, 2-isopropoxy-(2-isopropyl-5-methyl-cyclohexyloxy)-phosphoryl amino acid esters, were synthe-
1
sized in the presence of sulfuryl chloride with reasonable yields. Their structures were confirmed by IR, H
13 31
NMR, C NMR, P NMR and MS spectra, and the antibacte
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