对乙酰氨基酚与出生缺陷讲诉.pptVIP

孕期应用对乙酰氨基酚 与出生缺陷的风险 Findings From the National Birth Defects Prevention Study Marcia L. Feldkamp, PhD, Robert E. Meyer, PhD VOL. 115, NO. 1, JANUARY 2010 To investigate whether exposure during the first trimester of pregnancy to single-ingredient acetaminophen increases the risk of major birth defects. The usual recommended dose of acetaminophen is close to its toxic adult dose (the therapeutic index is narrow), raising concern for maternal overdose and fetal toxicity (对乙酰氨基酚90%~95%在肝脏代谢.每天总量不超过2克，是安全的。若每天服用该药的总量超过4克，则可致肝损害；大于10克，患者有可能因肝衰竭而死亡。) A recent study found that 65.5% of women repo