影响PIH患者远期原发性高血压的相关因素.docVIP

影响PIH患者远期原发性高血压的相关因素 季丹 (长宁区妇幼保健院产科上海长宁200051) 目的通过比较妊娠高血压综合征(妊高症)妇女和非妊高征妇女远 期原发性高血压的发病情况及血压水平，探讨可能影响妊高症妇女远期血压水平 的危险因素。方法采用回顾性队列研究设计，收集2000年1月至2010年12 月期间在我院住院分娩的936例孕妇资料，根据是否患妊高征分为妊高症组与非 妊高症组。随访3?13年，于2013年1月至2013年6月收集研究对象原发性高 血压发病情况及相关资料进行分析。结果妊高症组和非妊高症组的原发性高血 压累积发病率分别为45.8%和11.4%,妊高症组高于非妊高症组(P0.05)；在3 个不同年龄段中，妊高症患者高血压患病率均明显高于非妊高症组(P0.05)o随 访3?23年，随访时妊高症组和非妊高症组体质指数(BMI)分别为 (24.4plusmn;2.9)kg/m2 和(23.9plusmn;2.5) kg/m2,血胆固醇分别为 (5.45plusmn;0.37) mmol/L 和(5.04plusmn;0.23) mmol/L,空腹血糖分别为 (5.7plusmn;1.8mmol/L)^n(5.4plusmn;l.lmmol/L),差异均有统计学意义(PV 0.05)。校正年龄、BMI等影响因素后，妊高症对收缩压水平有一定的影响(P0.05), 空腹血糖也与收缩压水平相关，而年龄、BMI、白细胞计数和尿酸对远期收缩压 和舒张压均有影响。结论妊高症妇女远期原发性高血压累积发病率高于非妊高 症者；校正年龄、BMI等影响因素后，妊高症与远期收缩压水平相关。BMK空 腹血糖和胆固醇水平升高可能是妊高症患者远期血压水平升高的危险因素。 关键词 妊高症；危险因素；随访研究 R714.25 A 2095-1752 (2015) 16-0217-03 JI Dan JI Dan Department of Obstetrics , Changning District Maternity Hospital, Shanghai changning 200051, China Abstract] Objective To explore the perpetual impact of pregnancy-induced hyperte nsion on blood pressure. Methods This retrospective cohort study in eluded 936 cases of pregnant women who hospitalized at our hospital from January 2000 to December 2010. Patients were divided into two groups as pregnancy induced hypertension group (PIH, n二96) and non pregnancy induced hypertension group (NPIH, n二840). Patients were followed up for 3 to 13 years. The incidenee of essential hypertension was obtained in January 2013 to June 2013. Results The incidence of essential hypertension during follow up was significantly higher in PIH group(45.8%) than that in NPIH group (11.4%) (P0.05). In three different age ranges, the incidenee of hypertension in patients of observation group was significantly higher than that of control group(Plt;0.05). At the final follow up, BMI [(24.4plusmn;2.9) kg/m2 vs (23.9plusmn;2.5) kg/m2], TC [(5.45plusmn;0.37) mmol/L vs (5.04plusmn;0.23) mmol/L] and glucose [(5.47plusmn;1.8) mmol/L vs (5.4plusmn;1.14)mmol/L,] were all significantly higher in PIH