散结明目片治疗玻璃体积血的实验研究-中西医结合临床专业论文.docxVIP

— — PAGE 1— 摘 要 散结明目片治疗玻璃体积血的实验研究 研究生：董承新 导师：李全智教授 摘 要 目的：通过观察散结明目片对实验性玻璃体积血吸收作用和对视网膜组织变化影 响，以及玻璃体中超氧歧化酶和铁离子变化，对其疗效及其机理进行说明。方法： 用兔自体血造成玻璃体积血模型，设空白对照组、模型组、和血名目片组、散结名 目片高剂量组、中剂量组及低剂量组，6 周后观察各组玻璃体内积血和视网膜组织的 变化，以及铁离子（Fe2+）、超氧化物歧化酶（SOD）浓度的变化。结果： 铁离子浓 度示空白组与模型组、和血明目片组、散结明目片低剂量组、散结明目片中剂量组、 散结明目片高剂量组比较 P0.01。模型组组与和血明目片组、散结明目片低剂量组、 散结明目片中剂量组、散结明目片高剂量组比较 P0.003。和血明目片组与散结明目 片中剂量组比较 P0.01。散结明目片中剂量组与散结明目片高剂量组比较 P0.01。 SOD 浓度示空白组与模型组、和血明目片组、散结明目片低剂量组、散结明目片中 剂量组、散结明目片高剂量组比较 P0.01。模型组与和血明目片组、散结明目片低 剂量组、散结明目片中剂量组、散结明目片高剂量组比较 P0.003。和血明目片组与 散结明目片高剂量组比较 P0.01。散结明目片低剂量组与散结明目片高剂量组比较 P0.003。结论：散结明目片能促进玻璃体积血吸收，抑制眼内增殖性改变的发生与 发展。其机理与促进铁离子清除和 SOD 活性提高，避免玻璃体积血对视网膜的毒害 有关。 关键词：散结明目片 ;玻璃体积血; 铁离子；超氧化物歧化酶 新疆医科大学医学硕士学位论文 Sanjie Mingmu tablets on absorption of vitreous hemorrhage Experimental observation Abstract Objective: To discuss the healing effect and mechanism by observing the absorption of vitreous hemorrhage,the influence of retina and the concentration of SOD and Fe2+ in vitreous body with the San Jie Ming Mu tablet.Methods: Selecting Japan white rabbits. The models of vitreous hemorrhage were induced with autoblood in rabbits eyes. They were divided into Blank control group、model group、positive control group treated with He xue ming mu tablet、and the low、medium、high quantity groups of San jie ming mu tablet.Examine the concentration of Fe2+and SOD in the vitreous after 6 weeks.Result: Compared with the Blank control group,the model group、the group treated with He xue ming mu tablet and the San jie ming mu tablet with high-dose 、 medium-dose and low-dose group showed lower quantity of Fe2+ (P0.01)；compared with the model group， the group treated with Hexuemingmu tablet and the Sanjiemingmu tablet with high-dose、medium-dose and low-dose group have significant difference respectively(P0.003)；comlpared with the group treated with He xue ming mu tablet， medium quantity group of San jiemingmu tablet group have significant difference respectively(P0.01)；there are significant difference between