抗感染治疗性应用的基本原则.ppt

* * * * * * * This schematic diagram from Journal of clinical investigation illustrates the mechanism of resistance in MRSA. Methicillin resistance requires the presence of the chromosomally localized mecA gene. The mec A gene is the gene responsible for methicillin resistance and is part of a mobile genetic element found in many MRSA strains called SCCmec. To date, There are at least five different SCCmec elements. These elements integrate at the same time site in the chromosome by a mechanism involving site-specific recombination and excision from the chromosome at attBscc, that is a par