硫酸钙人工骨修复兔干骺端骨缺损的实验研究-外科学(骨科)专业论文.docxVIP

浙江大学硕士(临床七年制)学位论文Experimental 浙江大学硕士(临床七年制)学位论文 Experimental study on articular cartilage changes repaidng metaphyseal bone defect with calcium sulfate Abstract In this work,the morpholo百c changes of articular cartilage with bone grafting to fill subchondral bone defects were studied in rabbits．Twenty three-month-old New Zealand rabbits with bilateral fibial subchondral bone defects were investigated in this study．The defects were made about 5mm bclow the articular surface and were covered with surrounding tissue．The right side was filled with calcium sulfate bone graft,and the left side was fdled with acrylic cement as contr01．The articular cartilage above the fillers was harvested 12 weeks after the operation．Gross observation, histological examination and transmission electron microscope observation were undertaken．The results showed that cartilage above the calcium sulfate had a normal hyaline articular cartilage appearance．In contrast,cartilage above the acrylic cement showed degenerative changes in both histological and electron microscope observation．These results suggest that using calcium sulfate bone graft to fill subohondral metaphyseal bone defects has no harmful effect to overlying articular cartilage．Use of tMs substitute can reduce the possibility of osteoarthrifis compared to acrylic cement Key words bone graft，cartilage，chondrocyte,collagen 浙江大学硕士(临床七年制)学位论文浙江大学 浙江大学硕士(临床七年制)学位论文 浙江大学 学位论文原创性声明 本人郑重声明：所呈交的学位论文，是本人在导师的指 导下，独立进行研究工作所取得的成果。除文中已经注明引 用的内容外，本论文不包含任何其他个人或集体已经发表或 撰写过的作品成果。对本文的研究作出重要贡献的个人和集 体，均已在文中以明确方式标明。本人完全意识到本声明的 法律结果由本人承担。 学位论文作者签名：。磊绵力是 日期：cb]年岁月f f日 浙江大学硕士(临床七年制)学位论文浙江大学 浙江大学硕士(临床七年制)学位论文 浙江大学 学位论文版权使用授权书 本学位论文作者完全了解学校有关保留、使用学位论文的规定， 同意学校保留并向国家有关部门或机构送交论文的复印件和电子版， 允许论文被查阅和借阅。本人授权浙江大学可以将本学位论文的全部 或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等 复制手段保留和汇编本学位论文。 保密口，在—年解密后适用本授权书。 本学位论文属于 ，， 不保密匹 (请在以上方框内打“v／”) 学位论文作者签名j鲥 指 导 教 师 越致 日期娴年夕月f1日 日 期 朋M 0 ．必 签压下● 浙江大学硕士(临床七年制)学位论文Introduction 浙江大学硕士(临床七年制)学位论文 Introduction Numerous bone graft opera