课件：ESBL现状与治疗对策.pptx

ESBL;NEJM 362;19 nejm.org may 13, 2010;超广谱β-内酰胺酶;History of Drug resistant- ESBLs;β-内酰胺酶的类种及其特性;质粒（plasmid）;2008年度卫生部全国细菌耐药监测（Mohnarin）结果;革兰阴性杆菌分布;26957株大肠埃希菌的耐药率;16395株肺炎克雷伯菌的耐药率;结论（1）;结论（2）;结论（3）;ESBLs的发生率逐年上升;Prevalence of ESBLs CHINET surveillance, China, 2005-2008;Resistance of strains producing extended-spectrum beta-lactamases and genotype distribution in China ;Cantón R, Coque TM. Curr Opin Microbiol. 2006;9:466-75;CTX-M-3 29.4%;2008年12家医院大肠埃希菌的耐药率（%）;12家医院大肠埃希菌的耐药特点;2008年12家医院克雷伯菌属的耐药率（%）;;12家医院克雷伯菌属的耐药特点;ESBL Vs non-ESBLClinical success rate of 1st line AB ; ESBL Vs non-ESBLT