不同剂量叶酸联合降压治疗对高血压患者靶器官的保护作用.docxVIP

不同剂量叶酸联合降压治疗对高血压患者靶器官的保护作 用 广东省佛山市南海区罗村医院内一科 【摘要】目的：观察不同剂量叶酸联合降压治疗对高血压患者多个靶器官 的保护作用。方法：选择本院收治的300例高血压患者，随机分成A、B、C三 组。A组为对照组，采用常规降压治疗；B组、C组为实验组采用不同剂量叶酸 联合降压治疗。观察三组患者Hey、肾功能、心脏事件、脑卒中等情况。结果: 实验组Hey水平明显下降，肾功能明显改善，心脑血管时间发生率降低，和对照 组相比较有统计学意义(plt;0.001),但两实验组间对比没有显著意义 (pgt;0.05)o结论：叶酸联合降压治疗能降低高血压患者心脑血管事件发生率, 对多个靶器官有保护作用，但相对服用5mg叶酸联合降压治疗高血压，单纯加 大剂量叶酸服用量对保护高血压患者多个靶器官没有显著意义。 【关键词】叶酸、剂量、高血压、靶器官、心脑血管、肾功能 foshan 佛山市医学类科技公关项目，项目编号：201208130 [Abstract] Objective To observe the protective effects of d iff ere nt doses of folic acid combined with anti-hypertensive treatment treatment on multiple target organs in patients with hypertension. Methods Select my hospital 300 cases of hypertension patients were randomly divided into B, A, C three groups.A group as the control group, the use of conventional anti-hypertensive treatment;B group and C group were treated with different doses of folic acid in the experimental group.Observe the three groups of patients with Hey, renal function, cardiac events, stroke, etc.. Results The level of Hey in experimental group decreased sign讦icantly, renal function improved significantly, reduce the incidenee of cardiovascular and cerebrovascular time, compared with the control group had statistical significance (plt;0.001).But there was no significant differenee between the two experimental groups (pgt;0.05). Conclusion The treatment of folic acid combined with blood pressure can reduce the incidenee of cardiovascular events in patients with hypertension, has a protective effect on multiple target organs, But the relative use of 5mg folic acid combined with an ti-hypertensive treatme nt of high blood pressure, only to in crease the dose of folic acid to protect hypertensive patients with multiple target organs is not significant. 【Key words]Folic acid, dosage, high blood pressure, target organ, cardiovascular and cerebrovascular, renal function 高血压是我国主要多发性慢性病之一，同时也是心脑血管病最主要的危险因 素，其主要并发症有：脑卒中、心肌梗死、心力衰竭及慢性肾脏病等，不仪致残、 致死率也极高。根据《中国高血压指南》2010年版的治疗原则，约有3/4的