利培酮治疗精神分裂症的临床有效性分析与报告.docxVIP

利培酮治疗精神分裂症的临床有效性分析与报告 云南省大理州第二人民医院671000 摘要：目的：研究利培酮治疗精神分裂症的临床有效性。方法：病例资料来源于 我院2014年3月?2015年11月就诊的80例精神分裂症患者。所有患者给予利 培酮进行治疗，总结：(1)总有效率；(2)利培酮治疗副作用发生情况；(3)治 疗前、治疗2周、治疗4周、治疗8周患者PANSS总分、阳性评分、阴性评分、 精神病理评分的差异。结果：(1)80例患者中，治愈14例，显效20例，有效 40例，无效6例，总有效率达到92.50%； (2) 80例患者中，失眠5例，肌张力 增高4例，震颤2例，静坐不能2例，所有患者均未出现肝肾功能异常，基木均 可耐受，无需停药。(3)干预后2周、4周和8周患者PANSS总分、阳性评分、 阴性评分、精神病理评分跟干预前对比明显改善，PV0.05。结论：利培酮治疗 精神分裂症的临床有效性高，治疗效果确切，H副作用可耐受，具有较好的安全 性，可有效改善患者阳性、阴性症状，值得推广。 关键词：利培酮；精神分裂症；临床有效性 【abstract 】 objective： to study the effectiveness of risperidone in the treatment of schizophrenia. Methods： the clinical data from our hospital in March 2014-2015 of 80 cases of schizophrenia patients in November. All patients treated with risperidone, con eluded： (l)the total effective rate； (2) risperidone treatme nt side effects occur； (3) before treatment，treatment 2 weeks, 4 weeks, 8 weeks treatment in patients with PANSS score, positive rate and negative ratings, the differences between the mental pathological grading. Results： (1) in 80 patients, 14 cases cured, 20 cases were markedly effective, 40 cases effective, 6 no effect, the total effective rate of 92.50%； (2), 80 patie nts of in som nia in 5 cases, 4 cases were in creased muscle tone, tremor in 2 cases, akathisia in 2 cases, all patients were abnormal liver and kidney function, basic can be tolerated, no drug withdrawal. (3) 2 weeks, 4 weeks and 8 weeks after intervention in patients with PANSS scores, positive ratings, negative score, mental pathological grading with pre-intervention contrast markedly improved, P lt; 0.05) ? Conclusion： the high effectiveness of risperidone in the treatment of schizophrenia, the treatment effect is exact, and side effects can be toleranee, good security, which can effectively improve the symptoms of patients with positive and negative, is worth promoting. 【key words 】risperidone. Schizophrenia； Clinical effectiveness 精神分裂症为临床常见精神病，国内对于利培酮治疗精神分裂症 效果的研究对象多为接受过其他抗精神病药物治疗的患者，因而导致对利培酮治 疗疗效和安全性的评价产生影响［1-2］o本研究选取首