中药配方颗粒猫爪草提取液喷雾干燥工艺的研究.pdfVIP

Pharmacy Information 药物资讯, 2018, 7(1), 1-6 Published Online January 2018 in Hans. /journal/pi /10.12677/pi.2018.71001 Research on Spray Drying Technology of Radix Ranunculi Ternati Formula Granules Extract Solution * Xingqi Qin, Xizhen Wang , Shanyang Ye, Bijian Ban, Yan Huang, Dongju Wei PuraPharm (Nanning) Pharmaceutical Company Limited, Nanning Guangxi th th th Received: Dec. 29 , 2017; accepted: Jan. 9 , 2018; published: Jan. 16 , 2018 Abstract Objective: To study the effect of different excipients on wall sticking by spray drying of radix ra- 4 nunculi ternati formula granules extract solution. Method: Using the L9 (3 ) orthogonal design me- thod, powder collecting ratio and moisture content as the indicators, to investigate the influence of β-cyclodextrin, calcium oxide and inlet air temperature on radix ranunculi ternati spray drying, optimize the spray drying technology. Results: The amount of calcium oxide has a significant effect on powder collecting ratio (P 0.025), and the inlet air temperature has a significant effect on mois- ture content (P 0.05). Conclusions: The best spray drying technology is 14.8% soluble starch, 12% β-cyclodextrin, 0.2% calcium oxide and inlet air temperature is 185˚C. This technology is reasona- ble and feasible, which can offer the experimental basis for industrialized production. Keywords Radix Ranunculi Ternati, Spray Drying, Wall Sticking 中药配方颗粒猫爪草提取液喷雾干燥工艺的 研究 * 覃兴奇，王熙珍 ，叶善洋，班必剑，黄 艳，韦冬菊 培力(南宁)药业有限公司，广西 南宁 收稿日期：2017年12月29 日；录用日期：2018年1月9 日；发布日期：2018年1月16 日 *通讯作者。 文章引用: 覃兴奇, 王熙珍, 叶善洋, 班必剑, 黄艳, 韦冬