口腔鳞癌中DCs浸润的临床意义.docx

口腔鳞癌中DCs浸润的临床意义 万敏1冯红超2宋宇峰(通讯作者)3 (1遵义市第五人民医院口腔科贵州遵义563000) (2贵阳市口腔医院口腔外科 贵州 贵阳550001) (3贵阳医学院口腔颌面外科 贵州 贵阳550001) 【摘要】目的:研究口腔鳞癌组织(OSCC)中树突状细胞(DCs)的浸润密度的 临床意义。方法：采用免疫组织化学染色S?P法检测SJ00表达标记DCs,根据 临床情况进行统计学分析。结果：OSCC中DCs浸润密度低于正常对照组(P=0.016), 无转移组OSCC组织内DCs明显高于转移组，(P=0.010)o DCs浸润密度I gt; II gt;III级，(P二0.030)。结论：DCs浸润密度与OSCC分化程度及转移关系密切，DCs 在抑制肿瘤肿瘤发展、转移中起到一定的作用。 【关键词】口腔鳞癌；树突状细胞；淋巴结转移 【中图分类号】R78 【文献标识码】A 【文章编号】2095-1752 (2015) 10-0134-03 Clinical Significanee of Dendritic Cells Infiltration in Oral Squamous -cell Carci noma Wan Mini, Feng Hongchao2, Song Yufeng3 l.Department of Stomatology, The Fifth Peoples Hospital of Zunyi City, Zunyi 563000,China;2.Oral Surgery, Guiyang Stomatological Hospital, 550001,China;3.Department of Oral and Maxillary Surgery, Hospital of Guiyang Medical College, Guiyang, 550004, China 【Abstract] Objective To investigate dendritic cells(DCs) infiltration to assess their sign讦icances in the metastasis and prognosis in the oral squamous-cell carcinoma (OSCC) ? Methods Immunohistochemistry S-P method was adopted to ident 讦 y DCs infiltratio n, S? 100 protei n was used to mark DCs. Results DCs in filtration in normal oral mucosa were sign讦icantly higher in OSCC ( P = 0.016). The density of DCs in the group with lymph no des metastasis was clearly lower tha n in the group with no lymph no des metastasis in OSCC (P=0.010)? The den sity of DCs were obviously decreased alo ng differentiate on o f tumor, I gt; II (P=0.030)? Conclusion DCs infiltration was closely associated with tumor differentiation and lymph nodes metastasis, might inhibit the tumor progressi on and lymph no des metastasis in OSCC. 【Key words] Oral squamous-cell carci noma (OSCC); Den dritic cells(DCs) lymph no des metastasis 口腔鳞癌(oral squamous-cell carcinoma, OSCC)为口腔癌中最常见的恶性 肿瘤，有资料显示OSCC占90%,男性明显高于女性，发病年龄以40-60岁多见 [1-2]o机体的抗肿瘤免疫以T细胞介导的细胞免疫起主要作用，而树突状细胞 (dentritic cells, DCs)是激活T细胞的主要抗原提呈细胞,DCs是来自骨髓造血 干细胞并主要在骨髓分化形成的具有多种生物学效应的一类免疫细胞，因其具有 强大的抗原提呈能力和诱导初始T细胞活化的能力，被认为是体内功能最强的抗 原提呈细胞(antigen