相容性研究阿昔洛韦和乳糖的物理混合物和商业的片剂.pdf

European Journal of Pharmaceutics and Biopharmaceutics 73 (2009) 404–413 Contents lists available at ScienceDirect European Journal of Pharmaceutics and Biopharmaceutics journal homepage: www.else /locate/ejpb Research paper Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets Farnaz Monajjemzadeh a,d, Davoud Hassanzadeh a,e,*, Hadi Valizadeh a,d, Mohammad R. Siahi-Shadbad a,d, Javid Shahbazi Mojarrad b,f, Thomas A. Robertson c, Michael S. Roberts c a Department of Drug and Food Control, Tabriz University of Medical Sciences, Tabriz, Iran b Department of Medicinal Chemistry, Tabriz University of Medical Sciences, Tabriz, Iran c School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia d Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran e Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran f Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran a r t i c l e i n f o a b s t r a c t Article history: This study documents drug–excipient incompatibility studies of acyclovir in physical mixtures with lac- Received 27 May 2009 tose and in different tablet brands. Differential scanning calorimetry (DSC) was initially used to assess Accepted in revised form 22 June 2009 compatibility of mixtures. The Fourier-transform infrared (FTIR) spectrum was also compared with the Available online 23 July 2009 spectra of pure drug and excipient. Although DSC results indicated incompatibility with lactose,