肝内胆管癌预后评估系统的研究现状及展望·综述-中国肿瘤临床.PDFVIP

中国肿瘤临床2017年第44卷第11期 ChinJClinOncol2017.Vol.44.No.11 567 综 述 · · 肝内胆管癌预后评估系统的研究现状及展望* 王洋 袁筑慧 郑加生 综述 李威 审校 摘要 肝内胆管癌（intrahepaticcholangiocarcinoma，ICC）是一种罕见的原发肝脏恶性肿瘤，发病率仅次于肝细胞癌（hepatocellular carcinoma，HCC）。目前手术切除是公认的首选治疗手段，但与HCC相比，ICC的预后较差，且目前尚无权威的预后评估系统。近 10年来，学者提出多达12项针对手术切除ICC后的预后评估系统，包括传统的TNM分期系统、列线图预后系统等，但均未得到广 泛的认可和验证，本文从实用性、准确性等角度对这些预后评估系统做一综述。 关键词 肝内胆管癌 预后 TNM 列线图 doi:10.3969/j.issn.1000-8179.2017.12.110 Current status and prospect of prognostic systems for intrahepatic cholangiocarcinoma Yang WANG, Zhuhui YUAN, Jiasheng ZHENG, Wei LI Correspondence to: Wei LI; E-mail: vision988@ 126.com Center of Interventional Oncology and Liver Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China This work was supported by the Beijing Talents Project, Funding for High-level Talents in Beijing Municipal Health System (No. 2014-3- 088) and the National Major Scientific Instruments and Equipment Development Project (No. ZDYZ2015-2) Abstract Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatobiliary cancer after hepatocellular carci- noma (HCC). Surgical resection is the main curative treatment for ICC. Patients with ICC exhibit poorer prognosis compared with those with HCC. A comprehensive individualized prognostic system must be developed based on specific factors of patients. Several distinct prognostic staging systems have been proposed for patients with ICC treated by surgery. These systems include six staging systems, two scoring systems, and three prognostic nomograms. However, all of these prognostic systems are based on data from patients un- dergoing surgery resection and have not been validated in patients receiving other therapies. In this review, we will discu