阿立哌唑 博思清 与奋乃静治疗精神分裂症疗效研究.docxVIP

阿立哌卩坐(博思清)与奋乃静治疗精神分裂症疗效研究 胡洪彬 四川省乐山市五通桥区精神病医院四川省乐山市614800 摘要：目的：探讨阿立哌“坐与奋乃静治疗精神分裂症的疗效及不良反应对比 情况。方法：选择我院自2013年2月到2014年10月收治的70例精神分裂症患 者的临床资料，根据随机的原则，将患者分为治疗组35例与对照组35例，对照 组患者给予口服奋乃静，连续治疗8周，期间不给予应用其他抗精神病药物，但 必要时给予苯二氮草类药物，观察两组患者的临床疗效及不良反应发牛情况。结 果：对两组患者临床疗效进行分析发现，对两组患者临床疗效进行分析发现，治 疗组患者平均用药剂量为(29.5plusmn;3.8) mg/d,对照组平均用药剂量为 (32.7plusmn;3.8) mg/do两组患者治疗第8周PANSS、治疗后各阶段TESS评 分比较，结果具有显著性差异(Plt;0.05)o结论：阿立哌卩坐相治疗精神分裂症， 其疗效与奋乃静基木相当，但不良反应明显轻于奋乃静，是较为理想的治疗精神 分裂症的方法。 关键词：阿立哌哇；奋乃静；精神分裂 [Abstract]Objective To explore the curative effect of aripiprazole and perphenazine in the treatment of schizophrenia and adverse reaction of contrast.70 cases of mental methods in our hospital from 2013 February to 2014 October, clinical data of patients admitted to the division, according to the random principle, the patients were divided into treatment group 35 cases and control group 35 cases, control group were treated with oral perphenazine, continuous treatment for 8 weeks, the period does not give the application of other antipsychotics when necessary, but given the benzene two nitrogen grasses drugs, to observe the clinical efficacy and adverse reaction of two groups of patients the incidenee of.Results of the two groups of patients with clinical efficacy analysis found that patients in the treatme ntgroup, the average dose for (13.5 + 3.8) mg/d, the c on trol group mea n dose for (12.7 + 3.8) mg/d.Two groups of patients with efficiency comparison, no significant difference (Pgt;0.05)； the TESS score were compared between the two groups, the results have sign ificant d iff ere nee (Plt;0.05) .Con clusi on aripiprazole phase in the treatment of schizophrenia, its curative effect and perphenazine quite basic, but the adverse reaction was obviously lighter than Fen Naijing， method is ideal for the treatment of schizophrenia. [keyword]aripiprazole； perphenazine； schizophrenia 药物治疗是精神分裂症的重要治疗方法，奋乃静为临床较为常见的治疗精神 分裂的药物，但指出，奋乃静属高副反应发生率药物，且其剂量越大，副反应越 严重，且疗效并不增加。阿立哌畔，商品名博思清，是i种新型非典型抗精神病 药物，属卩奎“林类衍生物，对