缬沙坦和落汀新对原发性高血压伴左心室肥厚逆转作用比较地研究.docxVIP

英文摘要 1 999．②Echocardiogram，assessment of left ventricular Hypertrophy(LVH)：IVST1．17cm；LVPWT1．17cm：LVMI’S male 1 25e／m2 、 Female l 1 0e／m2,the HP8500GP echocardiography which made in American．The data was measured and noted by fixed doctor．@The patients must have stopped antihypertensive drugs for two weeks or have not taken ones before they were enrolled in the study．Exclusion criterion：The patients couldn’t stop antihypertensive drugs、The secondary hypertension、Coronary heart disease、Myocardium disease、Valvular heart disease、Diab·etes and Cerebrovascular diseaseand SO on． The subjects in this study were randomly divided into two treatment groups—Valsartan(80 and t60 me／day)group and Lotensin(1 0 and 20 me,／day)group．and have been followed—up， measured blood pressure Bid，taken echocardiograms 3 times among 8 months’treatment。The data were reconded．The age、Sex、Height and weight there were no significant difference in both groups． Result：1、The effect oflowing blood pressure：(Table 1) Blood pressure(BP)was decreased from 166_21／98+12mmHg to 1 30±8／82±6mmHg in Valsartan group：BP was decreased from 169±19／99±11mmHg to 140±9／88±7mmHg in Lotensin group．before and after 4 weeks’treatment，BP was decreased significantly f]PO．0 1)in both groups．there were Significant difference in both groupS(P0．05)． Hydrochlorthiazide(HCTZ)was given to patients whose blood 英文摘要 pressure still exceeded 1 40／90mmHg after 4 weeks for observing reverse effect of valsartan and lotensin On left ventricular hypertrophy ofprimary hypertension．5 patients have added HCTZ in the Valsartan group；1 2 patients have added HCTZ in the Lotensin group．However,Valsartan is more effective than Lotensin in decreasing blood pressure．2、The reverse effect left ventricular hypertrophy： both Valsartan and Lotensin can reverse significantly Ieft ventricular hypertrophy of primary hypertension，but there were no significant difference in both groups(PO．05)(Table 2)．1eft ventricularm