糊状纳米级羟基.pptVIP

INTRODUCTION 介绍 Biphasic ceramics are effective but not easy to use in certain circumstances 双相陶瓷效果可以，但有时使用不方便。 Phospho-calcic cements are more practical but less bioactive 含磷钙的产品比较实用， 但不具有生物活性。 It remains to find a injectable and bioactive substitute even osteo-inductive. 临床上需要一种可注射的具有生物活性， 甚至是骨诱导性的骨填充物。 50 proximal tibial open-wedge osteotomies 50例胫骨近端开放楔形截骨术 Oct. 02 to Feb. 04 2002年10月-2004年2月 Etiology : 病因 Especially Arthritis 48 cases 主要为关节炎48例 Post trauma. 2 cases 创伤 2例 23 F - 24 M (47 cases with 3 bilateral) 47例双侧 Age: 39 to 68 (average 51 years) 年龄：39-68（平均51） Follow-up 1 year (12 to 38 months) 跟踪1年( 12-38月） Pre-operative axis : varus 3° to 14° 术前轴线：内翻 3°-14° The goal is a valgus about 3°: 目标：外翻约3° (average correction = ?8?,7°) 平均矫正= 8.7° CHARACTERISATION 特点 Precipitation without fretting沉淀法制取，无高温烧结 分子式: Ca10(PO4)6(OH)2=HA羟基磷灰石 Ca/P 钙/磷原子比：(1,62-1,73) 1,675 Specific surface 有效表面积: 106 m2/g，比硫酸钙大30-50倍 Crystallites size微晶大小:18 nm (2 Theta = 25°) pH值: 7,5 ( 7,2 - 7,8) CLINICAL RESULTS 临床结果(superposable with those of the other addition techniques ) Pain 疼痛: - None or light无或轻微 = 88 % Moderated中= 9 % ; Severe严重 = 3 % Walk行走 : - unlimited不受限 = 31例 1-5 Km = 14例 ; 1Km = 2例 Use of sticks拄拐 : none无 = 45 ; one一支 = 2 RADIOLOGICAL RESULTS X线结果 ALL CONSOLIDATED 全部愈合  in 6 to 10 weeks 6-10周时间 except 2 delayed, 只有2例延迟 treated by immobilization during 2 months 制动2个月 Standard evolution标准进展 Other example 其它病例 Other example其它病例 COMPLICATIONS并发症 No pseudarthrosis, 2 consolidation delayed 无假关节，2例愈合延迟 No infection but 无感染 4 x asymptomatic light seepage 4例无症状体液轻微渗出 which dries itself up in 15 to 20 days without any treatment. 无须治疗15-20天自行干燥 BIOPSY 活检, 6 months 6个月  osteoblasts line成骨细胞   89% osteoblasts alive 89%成骨细胞存活 OSTIM? resorption奥速特?的吸收 The resorption is done by macrophages which invade the sit