BMI1和MINA53在胃癌组织及淋巴结转移灶中的手表达及意义.docxVIP

优秀毕业论文 精品参考文献资料 BMI． BMI．1和MINA53在胃癌组织及淋巴结转移灶中的表达及意义 为96．3％和1 00％(PO．05)，MINA53在伴淋巴结转移的胃癌原发灶 及其淋巴结转移灶中阳性表达率分别为92．6％和96．3％(PO．05)， 其差异无统计学意义。4．胃癌组织中BMI．1和MINA53的表达与患者的 性别、年龄无关(均P0．05)，而在肿瘤TNM分期和分化程度存在 显著性差异(PO．05)。5．BMI．1和MINA53表达存在正相关关系 (FO．720，PO．05)。 结论：1．BMI．1和MINA53在胃癌组织及淋巴结转移灶中的阳性表 达率明显增高，且二者表达呈正相关。2．BMI．1和MINA53与胃癌的 TNM分期、分化程度等临床病理特征相关，与患者性别、年龄、肿 瘤部位之间无相关。 关键词：胃癌；淋巴结转移灶；BMI．1；MINA53 万方数据 内蒙古大学硕士学位论文THE 内蒙古大学硕士学位论文 THE EXPRESSION AND PROGNOSTIC VALUE OF BMI．1 AND MINA53 IN SAMPLES FRoM GASTRIC CARCINoMAS AND LYMPH．NODE METASTASE S ABSTRACT Obj ective：To investigate the expression of BMI一1 and MINA5 3 in gastric cancer and lymph node metastasis，analyze the relationship between BMI．1 MINA5 3 and clinic pathological parameters，evaluate their role and significance in development of gastric cancer． Methods：The expression of BMI-1 and d MINA53 protein in Gastric cancer tissues and metastatic lymph nodes and corresponding adj acent normal gastric mucosa from 6 1 patients was analyzed using immunohistochemical method． Results：1．Ratio of positive expression of BMI-1 and MINA5 3 protein in gastric carcinomas lymph node metastases was 1 00％and 96．3％，respectively，ratio of positive expression of BMI一1 and MINA53 protein in gastric cancer was 86．9％and 82．O％，respectively，ratio of positive expression of BMI．1 and MINA5 3 protein in adj acent normal gastric mucosa was 6．7％and 6．7％，respectively，which were all significantly higher than that in normal gastric mucosa tissues，the differences between groups are statistically significant f，PO．05)．Ratio of positive expression of BMI．1 protein in none lymph node metastases 万方数据 BMI一 BMI一1和MINA53在胃癌组织及淋巴结转移灶中的表达及意义 and lymph node metastases was 79．4％and 96．3％，respectively(P O．05)，ratio of positive expression of MINA53 protein in none lymph node metastases and lymph node metastases was 73．5％and 92．6％， respectively(P0．05)，the differences between groups are statistically significant．Ratio of positive expression of BMI-1 protein in primary